Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.72 |
| ▸ | FLT1 | P17948 | 4/20 | 0.71 |
| ▸ | FLT4 | P35916 | 4/20 | 0.71 |
| ▸ | BRAF | P15056 | 6/20 | 0.63 |
| ▸ | RAF1 | P04049 | 4/20 | 0.63 |
| ▸ | KIT | P10721 | 1/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26697275 | 0.91 | KDR (0.68) | KDRFLT1FLT4BRAFRAF1 | |
| SCHEMBL26697330 | 0.91 | KDR (0.73) | KDRFLT1FLT4BRAFRAF1 | |
| SCHEMBL26894874 | 0.90 | BRAF (0.74) | KDRFLT1FLT4BRAFRAF1 | |
| SCHEMBL26697249 | 0.89 | KDR (0.72) | KDRFLT1FLT4BRAFRAF1 | |
| SCHEMBL26894919 | 0.88 | KDR (0.71) | KDRFLT1FLT4BRAFRAF1 | |
| SCHEMBL26697268 | 0.87 | KDR (0.70) | KDRFLT1FLT4BRAFRAF1 | |
| SCHEMBL26697206 | 0.86 | KDR (0.70) | KDRFLT1FLT4BRAFKIT | |
| SCHEMBL26697297 | 0.86 | KDR (0.69) | KDRFLT1FLT4KITPDGFRA | |
| SCHEMBL26697251 | 0.86 | KDR (0.70) | KDRFLT1FLT4BRAFKIT | |
| SCHEMBL26894876 | 0.85 | KDR (0.68) | KDRFLT1FLT4BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114920703-B | Quinazoline derivative and preparation method and application thereof | 天津济坤医药科技有限公司 | 2024-01-09 | — | — | CN | disclosed |
| WO-2023226323-A1 | QUINAZOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 天津济坤医药科技有限公司 | 2023-11-30 | — | — | WO | disclosed |
| WO-2023226323-A1 | QUINAZOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 天津济坤医药科技有限公司 | 2023-11-30 | — | — | WO | disclosed |
| CN-114920703-A | Quinazoline derivative and preparation method and application thereof | 天津济坤医药科技有限公司 | 2022-08-19 | — | — | CN | disclosed |