Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 18/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12021541 | 0.85 | GCK (0.51) | GCKKCNH2TP53 | |
| SCHEMBL12021481 | 0.80 | GCK (0.55) | GCKKCNH2 | |
| SCHEMBL12021355 | 0.78 | GCK (0.52) | GCKKCNH2 | |
| SCHEMBL12021520 | 0.73 | GCK (0.52) | GCKKCNH2TP53 | |
| SCHEMBL12021513 | 0.73 | GCK (0.49) | GCKTP53 | |
| SCHEMBL12021311 | 0.72 | GCK (0.60) | GCKKCNH2 | |
| SCHEMBL12021296 | 0.72 | GCK (0.52) | GCK | |
| SCHEMBL12021247 | 0.72 | GCK (0.75) | GCK | |
| SCHEMBL12021320 | 0.72 | NPC1 (0.53) | GCK | |
| SCHEMBL16674415 | 0.72 | GCK (0.49) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023718-A2 | NOVEL ACTIVATORS OF GLUCOKINASE | METABASIS THERAPEUTICS, INC. (US) | 2009-02-19 | — | — | WO | disclosed |