Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GSDMD | P57764 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylamine SCHEMBL28135383 | 1.00 | — | — | |
| Diethylamine SCHEMBL28011922 | 0.97 | TP53 (0.50) | TP53CYP3A4ALDH1A1ABCB11CYP2E1 | |
| Diethylamine SCHEMBL995759 | 0.84 | — | — | |
| Diethylamine SCHEMBL140450 | 0.82 | — | — | |
| Diethylamine SCHEMBL140448 | 0.82 | TP53 (0.80) | TP53CYP3A4ALDH1A1CYP2C19MEN1 | |
| Diethylamine SCHEMBL27862948 | 0.81 | TP53 (0.47) | TP53CYP3A4ALDH1A1ABCB11CYP2E1 | |
| Diethylamine SCHEMBL28532072 | 0.80 | — | — | |
| Diethylamine SCHEMBL995761 | 0.80 | TP53 (0.53) | TP53CYP3A4ALDH1A1KDM4ACYP2C19 | |
| Diethylamine SCHEMBL11282662 | 0.79 | TP53 (0.44) | TP53CYP3A4ALDH1A1ABCB11CYP2E1 | |
| Diethylamine SCHEMBL11830870 | 0.79 | TP53 (0.44) | TP53CYP3A4ALDH1A1ABCB11CYP2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632996-A2 | CATHODICALLY COLORING YELLOW SOLUBLE ELECTROCHROMIC AND LIGHT EMITTING POLYMERS | University of Florida Research Foundation, Incorporated (US) | 2013-09-04 | — | — | EP | disclosed |
| US-8519090-B2 | Cathodically coloring yellow soluble electrochromic and light emitting polymers | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2013-08-27 | — | — | US | disclosed |
| US-20130165614-A1 | CATHODICALLY COLORING YELLOW SOLUBLE ELECTROCHROMIC AND LIGHT EMITTING POLYMERS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-8399603-B2 | Cathodically coloring yellow soluble electrochromic and light emitting polymers | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2013-03-19 | — | — | US | disclosed |
| WO-2012058416-A9 | CATHODICALLY COLORING YELLOW SOLUBLE ELECTROCHROMIC AND LIGHT EMITTING POLYMERS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-08-16 | — | — | WO | disclosed |
| US-20120108778-A1 | CATHODICALLY COLORING YELLOW SOLUBLE ELECTROCHROMIC AND LIGHT EMITTING POLYMERS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-05-03 | — | — | US | disclosed |
| WO-2012058416-A2 | CATHODICALLY COLORING YELLOW SOLUBLE ELECTROCHROMIC AND LIGHT EMITTING POLYMERS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-05-03 | — | — | WO | disclosed |