Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 6/20 | 0.41 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | QPCT | Q16769 | 2/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | RORA | P35398 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | RORB | Q92753 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12205419 | 0.86 | ADORA2A (0.55) | ADORA2AADORA2BMCHR1CACNA1HLSS | |
| SCHEMBL26740897 | 0.85 | ADORA2A (0.50) | ADORA2AADORA2BMCHR1CACNA1HLSS | |
| SCHEMBL21430515 | 0.82 | MAPK8 (0.37) | CNR1CNR2GRM4KDM4EALDH1A1 | |
| SCHEMBL24645236 | 0.81 | ADORA2A (0.53) | ADORA2AADORA2BMCHR1CACNA1HLSS | |
| SCHEMBL21430514 | 0.81 | ADORA2A (0.53) | ADORA2AADORA2BMCHR1CACNA1HLSS | |
| Hydrochloric Acid SCHEMBL21409153 | 0.80 | ADORA2A (0.52) | ADORA2AADORA2BMCHR1CACNA1HLSS | |
| Hydrochloric Acid SCHEMBL29890861 | 0.80 | ADORA2A (0.52) | ADORA2AADORA2BMCHR1CACNA1HLSS | |
| SCHEMBL20421231 | 0.76 | KDM4E (0.62) | ADORA2AADORA2BCACNA1HKDM4EALDH1A1 | |
| SCHEMBL29988608 | 0.76 | KDM4E (0.62) | ADORA2AADORA2BCACNA1HKDM4EALDH1A1 | |
| SCHEMBL12083709 | 0.76 | KDM4E (0.56) | CNR1CNR2KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230357269-A1 | NEW MACROCYCLIC LRRK2 KINASE INHIBITORS | ONCODESIGN PRECISION MEDICINE (FR) | 2023-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230357269-A1 | NEW MACROCYCLIC LRRK2 KINASE INHIBITORS | LRRK2, RIN1, GRK3 | ADORA2A 1635/4885ADORA2B 1822/4885MCHR1 2745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.