Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 5/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 3/20 | 0.43 |
| ▸ | PTPRC | P08575 | 1/20 | 0.43 |
| ▸ | PTPRB | P23467 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 2/20 | 0.42 |
| ▸ | RXRB | P28702 | 2/20 | 0.42 |
| ▸ | RXRG | P48443 | 2/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.41 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2290372 | 0.90 | PTPN1 (0.47) | PPARDPPARGPTPN1PTPN2PTPN6 | |
| Bromide SCHEMBL2293962 | 0.87 | PTPRC (0.41) | PPARDPPARGPTPN1PTPN2PTPN6 | |
| Bromide SCHEMBL2296471 | 0.86 | PPARD (0.48) | PPARDPPARGALOX5PPARA | |
| Bromide SCHEMBL2292736 | 0.84 | HTR2A (0.38) | PPARDSLC6A4PPARA | |
| Bromide SCHEMBL2296444 | 0.80 | FFAR1 (0.43) | PPARGPTPN1SLC6A4 | |
| SCHEMBL4547677 | 0.79 | PPARD (0.44) | PPARDPPARGPTPN1PTPN2PTPN6 | |
| SCHEMBL2676421 | 0.79 | PPARD (0.48) | PPARDPPARGPTPN1PTPN2PTPN6 | |
| SCHEMBL4547681 | 0.79 | PTPN1 (0.47) | PPARDPTPN1PTPN2PTPN6PTPRC | |
| Bromide SCHEMBL2293888 | 0.79 | SLC1A5 (0.38) | PPARDPPARGHTR2CSLC6A4HTR2B | |
| SCHEMBL2676788 | 0.77 | MAOB (0.51) | PPARDPTPN1PTPN2PTPN6LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940808-B1 | DIFLUOROPHENOL DERIVATIVES AND THEIR USE | BAYER IP GMBH (DE) | 2013-11-27 | — | — | EP | disclosed |
| US-8173704-B2 | Difluorophenol derivatives and their use | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-05-08 | — | — | US | disclosed |
| US-20090291993-A1 | Difluorophenol Derivatives and Their Use | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2009-11-26 | — | — | US | disclosed |
| EP-1940808-A1 | DIFLUOROPHENOL DERIVATIVES AND THEIR USE | Bayer HealthCare AG (DE) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007045369-A1 | DIFLUOROPHENOL DERIVATIVES AND THEIR USE | BAYER HEALTHCARE AG (DE) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291993-A1 | Difluorophenol Derivatives and Their Use | TPMT, FABP3, DPP4 | PPARD 17/4885PPARG 73/4885PTPN1 143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.