Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 20/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL714220 | 0.94 | CHRM3 (0.59) | CHRM3 | |
| SCHEMBL3194562 | 0.92 | CHRM3 (0.59) | CHRM3 | |
| SCHEMBL3183764 | 0.91 | CHRM3 (0.61) | CHRM3 | |
| SCHEMBL266690 | 0.84 | CHRM3 (0.56) | CHRM3 | |
| SCHEMBL3543005 | 0.81 | CHRM3 (0.71) | CHRM3 | |
| SCHEMBL4432812 | 0.81 | CHRM3 (0.59) | CHRM3 | |
| SCHEMBL13592139 | 0.80 | CHRM3 (0.64) | CHRM3 | |
| SCHEMBL13590105 | 0.80 | CHRM3 (0.81) | CHRM3 | |
| SCHEMBL12909553 | 0.80 | CHRM3 (0.69) | CHRM3 | |
| SCHEMBL278884 | 0.79 | CHRM3 (0.77) | CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133905-B2 | Biphenyl compounds useful as muscarinic receptor antagonists | THERAVANCE, INC. (US) | 2012-03-13 | — | — | US | disclosed |
| US-8124627-B2 | Biphenyl compounds useful as muscarinic receptor antagonists | THERAVANCE, INC. (US) | 2012-02-28 | — | — | US | disclosed |
| US-7659403-B2 | Bronchodilators; treating chronic obstructive pulmonary disease or asthma; long duration of action; reduced side effects, such as dry-mouth and constipation; e.g. biphenyl-2-ylcarbamic acid 1-(2-[methyl(3-(2-[(thiophen-2-ylmethyl)amino]ethylcarbamoyl)benzoyl)amino]ethyl)piperidin-4-yl ester | THERAVANCE, INC. (US) | 2010-02-09 | — | — | US | disclosed |