Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 18/20 | 0.47 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2676284 | 1.00 | GCK (0.47) | GCKELOVL1KDM4EALDH1A1LMNA | |
| SCHEMBL2676282 | 1.00 | GCK (0.47) | GCKELOVL1KDM4EALDH1A1LMNA | |
| SCHEMBL2677377 | 1.00 | GCK (0.47) | GCKELOVL1KDM4EALDH1A1LMNA | |
| SCHEMBL2677316 | 1.00 | GCK (0.47) | GCKELOVL1KDM4EALDH1A1LMNA | |
| SCHEMBL2677310 | 1.00 | GCK (0.47) | GCKELOVL1KDM4EALDH1A1LMNA | |
| SCHEMBL2513488 | 0.90 | GCK (0.53) | GCK | |
| SCHEMBL2513491 | 0.90 | GCK (0.53) | GCK | |
| SCHEMBL2518137 | 0.79 | GCK (0.48) | GCK | |
| SCHEMBL2518134 | 0.79 | GCK (0.48) | GCK | |
| SCHEMBL2512876 | 0.78 | GCK (0.46) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116535-B1 | GLUCOKINASE-ACTIVATING SUBSTANCE | KYORIN SEIYAKU KK (JP) | 2014-06-11 | — | — | EP | claimed |
| US-20100016304-A1 | GLUCOKINASE ACTIVATOR | TEIJIN LIMITED (JP) | 2010-01-21 | — | — | US | claimed |
| US-8173649-B2 | Glucokinase activator | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2012-05-08 | — | — | US | disclosed |
| US-20100016304-A1 | GLUCOKINASE ACTIVATOR | TEIJIN LIMITED (JP) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016304-A1 | GLUCOKINASE ACTIVATOR | GCK, GCKR, GALK1 | GCK 1/4885ELOVL1 2287/4885KDM4E 3322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.