Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 15/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | FFAR2 | O15552 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2676652 | 1.00 | GCK (0.79) | GCKKCNH2FFAR2 | |
| SCHEMBL2677833 | 1.00 | GCK (0.79) | GCKKCNH2FFAR2 | |
| SCHEMBL2676653 | 1.00 | GCK (0.79) | GCKKCNH2FFAR2 | |
| SCHEMBL2677827 | 1.00 | GCK (0.79) | GCKKCNH2FFAR2 | |
| SCHEMBL2676257 | 1.00 | GCK (0.79) | GCKKCNH2FFAR2 | |
| SCHEMBL2676254 | 1.00 | GCK (0.79) | GCKKCNH2FFAR2 | |
| SCHEMBL2511547 | 0.89 | GCK (0.78) | GCKKCNH2FFAR2 | |
| SCHEMBL2512192 | 0.89 | GCK (0.78) | GCKKCNH2FFAR2 | |
| SCHEMBL2511545 | 0.89 | GCK (0.78) | GCKKCNH2FFAR2 | |
| Ro-281675 SCHEMBL2646000 | 0.88 | GCK (1.00) | GCKKCNH2FFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116535-B1 | GLUCOKINASE-ACTIVATING SUBSTANCE | KYORIN SEIYAKU KK (JP) | 2014-06-11 | — | — | EP | claimed |
| US-8173649-B2 | Glucokinase activator | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2012-05-08 | — | — | US | claimed |
| US-20100016304-A1 | GLUCOKINASE ACTIVATOR | TEIJIN LIMITED (JP) | 2010-01-21 | — | — | US | claimed |
| EP-2116535-B1 | GLUCOKINASE-ACTIVATING SUBSTANCE | KYORIN SEIYAKU KK (JP) | 2014-06-11 | — | — | EP | disclosed |
| US-8173649-B2 | Glucokinase activator | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2012-05-08 | — | — | US | disclosed |
| US-20100016304-A1 | GLUCOKINASE ACTIVATOR | TEIJIN LIMITED (JP) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016304-A1 | GLUCOKINASE ACTIVATOR | GCK, GCKR, GALK1 | GCK 1/4885KCNH2 342/4885FFAR2 1306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.