Sugi Predict

Sugi Predict / Compounds / SCHEMBL2677446

SCHEMBL2677446

SCHEMBL2677446

CCN(CC)CCn1cc(-c2cc(Oc3ccc4nc(NC(CO)CC(C)C)sc4c3)ccn2)cn1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CSF1R P07333 6/20 0.35
▸ TGFBR1 P36897 1/20 0.35
▸ FGFR1 P11362 2/20 0.33
▸ FGFR2 P21802 2/20 0.33
▸ FGFR4 P22455 2/20 0.33
▸ FGFR3 P22607 2/20 0.33
▸ KDR P35968 2/20 0.33
▸ LMNA P02545 1/20 0.33
▸ NPC1 O15118 3/20 0.33
▸ RAB9A P51151 3/20 0.33
▸ MAPT P10636 2/20 0.33
▸ SMN1; SMN2 Q16637 2/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ CYP2D6 P10635 1/20 0.33
▸ PIK3CD O00329 1/20 0.33
▸ PIP5K1C O60331 1/20 0.33
▸ PIK3CA P42336 1/20 0.33
▸ PIK3CB P42338 1/20 0.33
▸ PI4KA P42356 1/20 0.33
▸ PIK3CG P48736 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2677445 1.00 CSF1R (0.35) CSF1RTGFBR1FGFR1FGFR2FGFR4
SCHEMBL2678977 0.92 PIK3CD (0.40) CSF1RKDRLMNANPC1RAB9A
SCHEMBL2678973 0.92 PIK3CD (0.40) CSF1RKDRLMNANPC1RAB9A
SCHEMBL2676190 0.90 CSF1R (0.43) CSF1RFGFR1FGFR2FGFR4FGFR3
SCHEMBL2676189 0.90 CSF1R (0.43) CSF1RFGFR1FGFR2FGFR4FGFR3
SCHEMBL2677831 0.90 CSF1R (0.35) CSF1RTGFBR1FGFR1FGFR2FGFR4
SCHEMBL2677829 0.90 CSF1R (0.35) CSF1RTGFBR1FGFR1FGFR2FGFR4
SCHEMBL2676361 0.89 SYK (0.38) CSF1RFGFR1FGFR2FGFR4FGFR3
SCHEMBL2676357 0.89 SYK (0.38) CSF1RFGFR1FGFR2FGFR4FGFR3
SCHEMBL2676759 0.87 CSF1R (0.42) CSF1RKDRPDGFRAFLT3PDGFRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7553854-B2 6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2009-06-30 — — US claimed
US-8173689-B2 6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling NOVARTIS AG (CH) 2012-05-08 — — US disclosed
US-20100280006-A1 6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling NOVARTIS AG (CH) 2010-11-04 — — US disclosed
US-7553854-B2 6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2009-06-30 — — US disclosed
US-20080045528-A1 6-O-SUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF INHIBITING CSF-1R SIGNALING NOVARTIS AG 2008-02-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100280006-A1 6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling CSF1R, CSF3R, FLT3 CSF1R 1/4885TGFBR1 231/4885FGFR1 89/4885
US-20080045528-A1 6-O-SUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF INHIBITING CSF-1R SIGNALING CSF1R, CSF3R, FLT3 CSF1R 1/4885TGFBR1 231/4885FGFR1 89/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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