Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Isosorbide Mononitrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.78 |
| ▸ | BCHE | P06276 | 6/20 | 0.58 |
| ▸ | GSR | P00390 | 7/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isosorbide Mononitrate SCHEMBL8893635 | 1.00 | MAPT (1.00) | MAPTALDH1A1BCHEGSRCA2 | |
| Isosorbide Mononitrate SCHEMBL12238510 | 1.00 | MAPT (1.00) | MAPTALDH1A1BCHEGSRCA2 | |
| Isosorbide Mononitrate SCHEMBL8894719 | 1.00 | MAPT (1.00) | MAPTALDH1A1BCHEGSRCA2 | |
| Isosorbide Mononitrate SCHEMBL3056251 | 1.00 | MAPT (1.00) | MAPTALDH1A1BCHEGSRCA2 | |
| Isosorbide Mononitrate SCHEMBL616518 | 1.00 | MAPT (1.00) | MAPTALDH1A1BCHEGSRCA2 | |
| Isosorbide Mononitrate SCHEMBL5482432 | 1.00 | MAPT (1.00) | MAPTALDH1A1BCHEGSRCA2 | |
| Isosorbide Mononitrate SCHEMBL23906861 | 1.00 | MAPT (1.00) | MAPTALDH1A1BCHEGSRCA2 | |
| Isosorbide Mononitrate SCHEMBL12787633 | 1.00 | MAPT (1.00) | MAPTALDH1A1BCHEGSRCA2 | |
| Isosorbide Mononitrate SCHEMBL22067709 | 1.00 | MAPT (1.00) | MAPTALDH1A1BCHEGSRCA2 | |
| Isosorbide Mononitrate SCHEMBL8893344 | 1.00 | MAPT (1.00) | MAPTALDH1A1BCHEGSRCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 13317 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122070280-A | FPR1 modulators, compositions comprising the modulators, and methods of use thereof | 百放开曼有限公司 | 2026-05-19 | — | — | CN | claimed |
| EP-4736841-A1 | A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT | IQ medical GmbH (DE) | 2026-05-06 | — | — | EP | claimed |
| WO-2026090251-A1 | METHODS FOR IMPROVING TREATMENT OUTCOMES IN PATIENTS UNDERGOING ULTRAFILTRATION | PROLETARIAT THERAPEUTICS, INC. (US) | 2026-04-30 | — | — | WO | claimed |
| US-20260115188-A1 | METHODS OF TREATING CENTERAL NERVOUS SYSTEM DISORDERS COMPRISING ADMINISTERING DEUTERATED LUMATEPERONE AND A NITRIC OXIDE DONOR | INTRA-CELLULAR THERAPIES, INC. (US) | 2026-04-30 | — | — | US | claimed |
| EP-4731194-A1 | MATERIALS AND METHODS FOR MITIGATING THE PRESENCE OF NITROSAMINES IN PACKAGING USING AN ACTIVE AGENT | CSP Technologies, Inc. (US) | 2026-04-29 | — | — | EP | claimed |
| EP-4724049-A1 | MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF | Catalent Ontario Limited (CA) | 2026-04-15 | — | — | EP | claimed |
| EP-4691556-A2 | HUMANIZED ANTI-ACTH ANTIBODIES AND USE THEREOF | H. Lundbeck A/S (DK) | 2026-02-11 | — | — | EP | claimed |
| EP-4687805-A1 | MATERIALS AND METHODS FOR MITIGATING THE PRESENCE OF NITROSAMINES IN PACKAGING USING ACTIVATED CARBON OR A DERIVATIVE THEREOF | CSP Technologies, Inc. (US) | 2026-02-11 | — | — | EP | claimed |
| US-20260027008-A1 | MATERIALS AND METHODS FOR MITIGATING THE PRESENCE OF NITROSAMINES IN PACKAGING USING ACTIVATED CARBON OR A DERIVATIVE THEREOF | CSP TECHNOLOGIES, INC. | 2026-01-29 | — | — | US | claimed |
| WO-2025264260-A1 | MATERIALS AND METHODS FOR MITIGATING THE PRESENCE OF NITROSAMINES IN PACKAGING USING AN ACTIVE AGENT | CSP TECHNOLOGIES, INC. (US) | 2025-12-26 | — | — | WO | claimed |
| EP-0277741-A1 | Spherical granules having core and their production | Takeda Chemical Industries, Ltd. (JP) | 1988-08-10 | — | — | EP | claimed |
| EP-0266450-A1 | Process for the selective preparation of isosorbide-2-mononitrate from isosorbide-2,5-dinitrate | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 1988-05-11 | — | — | EP | claimed |
| EP-0240351-A2 | Method of preparing controlled longacting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics | Lowey, Hans (US) | 1987-10-07 | — | — | EP | claimed |
| US-4590207-A | USING ISOSORBIDE MONONITRATE | EISAI CO., LTD. (JP) | 1986-05-20 | — | — | US | claimed |
| EP-0150063-A2 | Therapeutic and/or preventive ophthalmic solution for intraocular hypertension and glaucoma | Eisai Co., Ltd. (JP) | 1985-07-31 | — | — | EP | claimed |
| EP-0067964-B1 | PROCESS FOR THE PREPARATION OF 2-ISOSORBIDE NITRATE | Heinrich Mack Nachf. (DE) | 1985-04-03 | — | — | EP | claimed |
| EP-0104877-A2 | Organic nitrate drug mixtures resistant to detonation by fire | ICI AMERICAS INC. (US) | 1984-04-04 | — | — | EP | claimed |
| US-4417065-A | ACYLATION OF ISOSORBIDE AND ESTERIFICATION WITH NITRIC ACID | HEINRICH MACK NACHF. CHEM.-PHARMAZEUTISCHE FABRIK (DE) | 1983-11-22 | — | — | US | claimed |
| EP-0067964-A2 | Process for the preparation of 2-isosorbide nitrate | Heinrich Mack Nachf. (DE) | 1982-12-29 | — | — | EP | claimed |
| US-4065488-A | Process for preparing 1,4:3,6-dianhydro-D-glucitol 2-nitrate | AMERICAN HOME PRODUCTS CORPORATION (US) | 1977-12-27 | — | — | US | claimed |