SCHEMBL26790804

SCHEMBL26790804

Cn1cnc2cc(C#C[Si](C)(C)C)c(Cl)c(F)c21

nearest known ligand 0.36

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 4/20 0.36
DPP8 Q6V1X1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26790797 0.87 DPP4 (0.33) DPP4
SCHEMBL26790873 0.83 DPP4 (0.34) DPP4DPP8
SCHEMBL26790803 0.82 DPP4 (0.38) DPP4DPP8
SCHEMBL26790843 0.77
SCHEMBL24463239 0.74 DPP4 (0.37) DPP4DPP8
SCHEMBL30390911 0.74 DPP4 (0.37) DPP4DPP8
SCHEMBL26790544 0.72 GRM5 (0.39)
SCHEMBL26790691 0.72 GRM5 (0.39) DPP4
SCHEMBL26790794 0.71 DPP4 (0.35) DPP4
SCHEMBL26790835 0.69 ADORA2A (0.31) DPP4DPP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230374015-A1 INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES KINNATE BIOPHARMA INC. 2023-11-23 US disclosed
US-20230374015-A1 INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES KINNATE BIOPHARMA INC. 2023-11-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230374015-A1 INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES FGFR1, FGFR2, FGFR3 DPP4 2192/4885DPP8 1200/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.