Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 12/20 | 0.68 |
| ▸ | FECH | P22830 | 1/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.40 |
| ▸ | SRPK1 | Q96SB4 | 3/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | FLT4 | P35916 | 2/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.40 |
| ▸ | BRSK1 | Q8TDC3 | 2/20 | 0.40 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | FER | P16591 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26799830 | 0.93 | CHEK1 (0.58) | CHEK1FECHKCNH2HRH3RPS6KA3 | |
| SCHEMBL16366493 | 0.89 | CHEK1 (0.71) | CHEK1FECHKCNH2RPS6KA3SRPK1 | |
| SCHEMBL16366039 | 0.87 | CHEK1 (0.69) | CHEK1FECHKCNH2RPS6KA3SRPK1 | |
| SCHEMBL13551232 | 0.83 | CHEK1 (0.75) | CHEK1FECHKCNH2RPS6KA3SRPK1 | |
| Rabusertib SCHEMBL304748 | 0.81 | CHEK1 (1.00) | CHEK1FECHKCNH2RPS6KA3SRPK1 | |
| Rabusertib SCHEMBL30403507 | 0.81 | CHEK1 (1.00) | CHEK1FECHKCNH2RPS6KA3SRPK1 | |
| Rabusertib SCHEMBL304747 | 0.81 | CHEK1 (1.00) | CHEK1FECHKCNH2RPS6KA3SRPK1 | |
| SCHEMBL18347830 | 0.80 | CHEK1 (0.59) | CHEK1FECHKCNH2RPS6KA3SRPK1 | |
| SCHEMBL18347838 | 0.79 | CHEK1 (0.58) | CHEK1FECHKCNH2RPS6KA3SRPK1 | |
| SCHEMBL304885 | 0.78 | CHEK1 (0.56) | CHEK1FECHKCNH2GSK3BKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11826430-B2 | Anti-cancer nuclear hormone receptor-targeting compounds | NUVATION BIO INC. (US) | 2023-11-28 | — | — | US | disclosed |
| US-11826430-B2 | Anti-cancer nuclear hormone receptor-targeting compounds | NUVATION BIO INC. (US) | 2023-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11826430-B2 | Anti-cancer nuclear hormone receptor-targeting compounds | NCOA1, NCOR1, NCOA3 | CHEK1 1233/4885FECH 2738/4885KCNH2 4878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.