Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glutamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 2/20 | 0.67 |
| ▸ | GRM6 | O15303 | 2/20 | 0.67 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.67 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.67 |
| ▸ | GSR | P00390 | 2/20 | 0.67 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.67 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.67 |
| ▸ | GRM5 | P41594 | 1/20 | 0.67 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.67 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.67 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.67 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.67 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.67 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.67 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.67 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.67 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.67 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL17962756 | 0.94 | GRM8 (0.75) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL28630462 | 0.94 | GRM8 (0.75) | GRM8GRM6GRM7GRM4GSR | |
| Glutamic Acid SCHEMBL9500095 | 0.94 | GRM8 (0.75) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL28870726 | 0.94 | GRM8 (0.75) | GRM8GRM6GRM7GRM4GSR | |
| Glutamic Acid SCHEMBL9308814 | 0.92 | GRM8 (0.72) | GRM8GRM6GRM7GRM4GSR | |
| Glutamic Acid SCHEMBL4195596 | 0.89 | GRM8 (0.72) | GRM8GRM6GRM7GRM4GSR | |
| Glutamic Acid SCHEMBL9617055 | 0.89 | GRM8 (0.72) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL1685060 | 0.88 | GSR (0.86) | GRM8GRM6GRM7GRM4GSR | |
| Glutamic Acid SCHEMBL2680379 | 0.88 | GSR (0.86) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL5673029 | 0.88 | GSR (0.86) | GRM8GRM6GRM7GRM4GSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993117-B2 | Devices with multiple surface functionality | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2015-03-31 | — | — | US | disclosed |
| US-20120121661-A1 | DEVICES WITH MULTIPLE SURFACE FUNCTIONALITY | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120114935-A1 | DEVICES WITH MULTIPLE SURFACE FUNCTIONALITY | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2012-05-10 | — | — | US | disclosed |
| US-7507483-B2 | Enhanced bonding layers on native oxide surfaces | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-03-24 | — | — | US | disclosed |
| US-20060194008-A1 | Devices with multiple surface functionality | PRINCETON UNIVERSITY (US) | 2006-08-31 | — | — | US | disclosed |
| US-20040023048-A1 | Enhanced bonding layers on native oxide surfaces | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120121661-A1 | DEVICES WITH MULTIPLE SURFACE FUNCTIONALITY | PHOSPHO1, CD44, SELP | GRM8 1521/4885GRM6 458/4885GRM7 1474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.