Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 7/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21952178 | 1.00 | USP2 (0.45) | USP2SMN1; SMN2GPR119RECQLKDM4E | |
| SCHEMBL30295739 | 1.00 | USP2 (0.45) | USP2SMN1; SMN2GPR119RECQLKDM4E | |
| SCHEMBL18330199 | 1.00 | USP2 (0.45) | USP2SMN1; SMN2GPR119RECQLKDM4E | |
| SCHEMBL38665956 | 1.00 | USP2 (0.45) | USP2SMN1; SMN2GPR119RECQLKDM4E | |
| SCHEMBL23172919 | 0.85 | USP2 (0.44) | USP2SMN1; SMN2GPR119RECQLHPGD | |
| SCHEMBL38665118 | 0.84 | USP2 (0.43) | USP2SMN1; SMN2GPR119RECQLKDM4E | |
| SCHEMBL19735994 | 0.84 | USP2 (0.43) | USP2SMN1; SMN2GPR119RECQLKDM4E | |
| SCHEMBL30626319 | 0.81 | USP2 (0.40) | USP2SMN1; SMN2GPR119RECQLHPGD | |
| SCHEMBL30626326 | 0.81 | USP2 (0.40) | USP2SMN1; SMN2GPR119RECQLHPGD | |
| SCHEMBL38666559 | 0.80 | USP2 (0.40) | USP2SMN1; SMN2GPR119RECQLKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4282416-A2 | PROCESS OF MANUFACTURE OF A COMPOUND FOR INHIBITING THE ACTIVITY OF SHP2 | Novartis AG (CH) | 2023-11-29 | — | — | EP | disclosed |