Nitramine

Nitramine

SCHEMBL2683709

CCCC.CN(c1c([N+](=O)[O-])cc([N+](=O)[O-])cc1[N+](=O)[O-])[N+](=O)[O-]

nearest known ligand 0.49

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.49
MEN1 O00255 2/20 0.49
HPGD P15428 2/20 0.49
NPSR1 Q6W5P4 1/20 0.49
HTT P42858 3/20 0.47
POLB P06746 1/20 0.44
ALDH1A1 P00352 6/20 0.43
CYP3A4 P08684 3/20 0.43
GPR35 Q9HC97 4/20 0.42
TDP1 Q9NUW8 5/20 0.42
MAPK1 P28482 4/20 0.42
TSHR P16473 2/20 0.42
MAPT P10636 4/20 0.41
KDM4E B2RXH2 2/20 0.41
TTR P02766 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C9 P11712 1/20 0.41
ALOX15 P16050 1/20 0.41
ALOX12 P18054 1/20 0.41
RECQL P46063 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nitramine SCHEMBL57161 0.93 KMT2A (0.54) KMT2AMEN1HPGDNPSR1HTT
Nitramine SCHEMBL27698408 0.91 KMT2A (0.53) KMT2AMEN1HPGDNPSR1HTT
Nitramine SCHEMBL28246776 0.91 KMT2A (0.53) KMT2AMEN1HPGDNPSR1HTT
Nitramine SCHEMBL28196454 0.91 KMT2A (0.53) KMT2AMEN1HPGDNPSR1HTT
Nitramine SCHEMBL11697129 0.91 KMT2A (0.53) KMT2AMEN1HPGDNPSR1HTT
Nitramine SCHEMBL6131363 0.91 KMT2A (0.53) KMT2AMEN1HPGDNPSR1HTT
Nitramine SCHEMBL22069954 0.91 KMT2A (0.53) KMT2AMEN1HPGDNPSR1HTT
Nitramine SCHEMBL9803294 0.88 KMT2A (0.54) KMT2AMEN1HPGDNPSR1HTT
Nitramine SCHEMBL11333778 0.88 KMT2A (0.54) KMT2AMEN1HPGDNPSR1HTT
Nitramine SCHEMBL28918761 0.87 KMT2A (0.42) KMT2AMEN1HPGDNPSR1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9914734-B2 Cyclic energetic nitramines desensitized with linear nitramines AEROJET ROCKETOYNE, INC. (US) 2018-03-13 US disclosed
US-20170233306-A1 PROPELLANT COMPOSITIONS COMPRISING NITRAMINE OXIDANTS AGENCY FOR DEFENSE DEVELOPMENT (KR) 2017-08-17 US disclosed
CN-103608088-A Process for chemical destruction of compounds from amine-based carbon capture SINVENT AS 2014-02-26 CN disclosed
US-20120111460-A1 Cyclic Energetic Nitramines Desensitized with Linear Nitramines AERO-JET-GENERAL CORPORATION (US) 2012-05-10 US disclosed
WO-2010120852-A1 CYCLIC ENERGETIC NITRAMINES DESENSITIZED WITH LINEAR NITRAMINES AEROJET-GENERAL CORPORATION (US) 2010-10-21 WO disclosed
CN-1985987-A Medicine composition of glycyrrhizic acid or its salt and reduced glutathione HUANG ZHENHUA (CN) 2007-06-27 CN disclosed
EP-0904531-B1 METHOD OF EXPLOSIVES DETECTION SECR DEFENCE (GB) 2002-09-25 EP disclosed
US-6245576-B1 ANALYZING SAMPLES FOR ENERGETIC MATERIALS; BY HEATING SAMPLES IN CHAMBER UNDER PRESSURE AND DETECTING CHEMILUMINESCENT EMISSION THE SECRETARY OF STATE FOR DEFENCE IN HER BRITTANIC MAJESTY'S GOVERNMENT OF THE UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND OF DEFENCE EVALUATION RESEARCH AGENCY (GB) 2001-06-12 US disclosed
EP-0904531-A1 METHOD OF EXPLOSIVES DETECTION THE SECRETARY OF STATE FOR DEFENCE (GB) 1999-03-31 EP disclosed
WO-1997047958-A1 METHOD OF EXPLOSIVES DETECTION THE SECRETARY OF STATE FOR DEFENCE (GB) 1997-12-18 WO disclosed
US-5520757-A Low vulnerability propellants ICI EXPLOSIVES USA INC. (US) 1996-05-28 US disclosed
US-5482581-A Low vulnerability propellant plasticizers ICI EXPLOSIVES USA INC. (US) 1996-01-09 US disclosed