Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 2/20 | 0.46 |
| ▸ | KDM5C | P41229 | 2/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21716654 | 0.85 | KDM5B (0.64) | KDM5AKDM5CKDM5BKDM4EALDH1A1 | |
| SCHEMBL26862853 | 0.79 | KDM5B (0.73) | KDM5AKDM5CKDM5BKDM4CSENP1 | |
| SCHEMBL16291539 | 0.77 | KDM5B (0.77) | KDM5AKDM5CKDM5BKDM4EALDH1A1 | |
| SCHEMBL26862778 | 0.76 | KDM5B (0.49) | KDM5AKDM5CKDM5BKDM4EALDH1A1 | |
| SCHEMBL21716656 | 0.74 | KDM5B (0.59) | KDM5AKDM5CKDM5BKDM4EALDH1A1 | |
| SCHEMBL26862781 | 0.73 | KDM5B (0.46) | KDM5AKDM5CKDM5BALDH1A1KDM4C | |
| SCHEMBL16912751 | 0.70 | KDM5B (0.55) | KDM5AKDM5CKDM5BKDM4EALDH1A1 | |
| SCHEMBL21716662 | 0.68 | KDM5B (0.84) | KDM5AKDM5CKDM5BKDM4EALDH1A1 | |
| SCHEMBL26862784 | 0.65 | KDM5B (0.71) | KDM5AKDM5CKDM5BKDM4EALDH1A1 | |
| SCHEMBL1471037 | 0.65 | HIF1A (0.49) | KDM4EALDH1A1HTR1ASENP1LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230382865-A1 | HISTONE DEMETHYLASE 5 INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230382865-A1 | HISTONE DEMETHYLASE 5 INHIBITORS AND USES THEREOF | KDM5A, KDM5B, KDM5C | KDM5A 1/4885KDM5C 3/4885KDM5B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.