SCHEMBL2689577

SCHEMBL2689577

O=[N+]([O-])c1ccc(Nc2ccccc2-c2ccccc2)c2nonc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MYC P01106 11/20 1.00
MAX P61244 7/20 0.81
MEN1 O00255 9/20 0.70
KMT2A Q03164 9/20 0.70
IDO1 P14902 4/20 0.70
POLB P06746 1/20 0.69
GAA P10253 1/20 0.69
L3MBTL1 Q9Y468 1/20 0.69
USP2 O75604 1/20 0.58
HTT P42858 1/20 0.58
RECQL P46063 1/20 0.58
PSMD14 O00487 1/20 0.53
MAPT P10636 1/20 0.53
RXFP1 Q9HBX9 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29386206 1.00 MYC (1.00) MYCMAXMEN1KMT2AIDO1
SCHEMBL16107698 0.95 MYC (0.91) MYCMAXMEN1KMT2AIDO1
SCHEMBL16139724 0.90 MYC (0.82) MYCMAXMEN1KMT2AIDO1
SCHEMBL17927377 0.87 MYC (0.77) MYCMAXMEN1KMT2AIDO1
SCHEMBL17927315 0.85 MYC (0.73) MYCMAXMEN1KMT2AIDO1
SCHEMBL17934467 0.85 MYC (0.73) MYCMAXMEN1KMT2AIDO1
SCHEMBL16139687 0.85 MYC (0.80) MYCMAXMEN1KMT2AIDO1
SCHEMBL16139693 0.85 MYC (0.79) MYCMAXMEN1KMT2AIDO1
SCHEMBL16139677 0.83 MYC (0.81) MYCMAXMEN1KMT2AIDO1
SCHEMBL16107551 0.83 MYC (0.85) MYCMAXMEN1KMT2AIDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7026343-B2 Pharmacologic inhibition of Myc function UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2006-04-11 US claimed
US-20040034060-A1 Pharmacologic inhibition of Myc function NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2004-02-19 US claimed
WO-2003105759-A2 PHARMACOLOGIC INHIBITION OF MYC FUNCTION UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2003-12-24 WO claimed
US-20250099539-A1 METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS MASSACHUSETTS EYE AND EAR INFIRMARY 2025-03-27 US disclosed
US-12239651-B2 Treatment of hearing loss MASSACHUSETTS EYE AND EAR INFIRMARY (US) 2025-03-04 US disclosed
US-12156899-B2 Methods and compositions for regenerating hair cells and/or supporting cells MASSACHUSETTS EYE AND EAR INFIRMARY (US) 2024-12-03 US disclosed
US-20240299432-A1 TREATMENT OF HEARING LOSS MASSACHUSETTS EYE AND EAR INFIRMARY 2024-09-12 US disclosed
US-12043653-B2 Efficient delivery of therapeutic molecules to cells of the inner ear MASSACHUSETTS EYE AND EAR INFIRMARY (US) 2024-07-23 US disclosed
US-11963968-B2 Treatment of hearing loss MASSACHUSETTS EYE AND EAR INFIRMARY (US) 2024-04-23 US disclosed
US-11852631-B2 Biomarkers predictive of anti-immune checkpoint response DANA-FARBER CANCER INSTITUTE, INC. (US) 2023-12-26 US disclosed
US-20230277574-A1 TREATMENT OF HEARING LOSS MASSACHUSETTS EYE AND EAR INFIRMARY 2023-09-07 US disclosed
US-20140296307-A1 POTENT ANALOGUES OF THE C-MYC INHIBITOR 10074-G5 WITH IMPROVED CELL PERMEABILITY UNIVERSITY OF MARYLAND, BALTIMORE (US) 2014-10-02 US disclosed
WO-2014039908-A1 METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS MASSACHUSETTS EYE AND EAR INFIRMARY (US) 2014-03-13 WO disclosed
US-8637556-B2 Linked Myc-max small molecule inhibitors University of Pittsburgh—of the Commonwealth System of Higher Education (US) 2014-01-28 US disclosed
WO-2012055170-A1 USE OF CYTOPLASMIC C-MYC FOR REGULATING IMMUNE RESPONSES THE UNIVERSITY OF HONG KONG (CN) 2012-05-03 WO disclosed
US-20120107317-A1 USE OF CYTOPLASMIC C-MYC FOR REGULATING IMMUNE RESPONSES THE UNIVERSITY OF HONG KONG (CN) 2012-05-03 US disclosed
WO-2010083404-A2 LINKED MYC-MAX SMALL MOLECULE INHIBITORS UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2010-07-22 WO disclosed
US-7026343-B2 Pharmacologic inhibition of Myc function UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2006-04-11 US disclosed
US-20040034060-A1 Pharmacologic inhibition of Myc function NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2004-02-19 US disclosed
WO-2003105759-A2 PHARMACOLOGIC INHIBITION OF MYC FUNCTION UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2003-12-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140296307-A1 POTENT ANALOGUES OF THE C-MYC INHIBITOR 10074-G5 WITH IMPROVED CELL PERMEABILITY MYC, MYCBP, MKI67 MYC 1/4885MAX 4/4885MEN1 204/4885
US-20240299432-A1 TREATMENT OF HEARING LOSS HES1, NOTCH1, NOTCH4 MYC 12/4885MAX 2554/4885MEN1 66/4885
US-20040034060-A1 Pharmacologic inhibition of Myc function MYCBP, MYC, MYCBP2 MYC 2/4885MAX 5/4885MEN1 1041/4885
US-20230277574-A1 TREATMENT OF HEARING LOSS HES1, NOTCH1, NOTCH4 MYC 12/4885MAX 2554/4885MEN1 66/4885
US-12043653-B2 Efficient delivery of therapeutic molecules to cells of the inner ear HES1, NOTCH1, NOTCH2 MYC 8/4885MAX 3943/4885MEN1 254/4885
US-12156899-B2 Methods and compositions for regenerating hair cells and/or supporting cells HES1, NOTCH1, NOTCH4 MYC 6/4885MAX 1556/4885MEN1 82/4885
US-20250099539-A1 METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS HES1, NOTCH1, NOTCH4 MYC 6/4885MAX 1556/4885MEN1 82/4885
US-12239651-B2 Treatment of hearing loss HES1, NOTCH1, NOTCH4 MYC 12/4885MAX 2554/4885MEN1 66/4885
US-11963968-B2 Treatment of hearing loss HES1, NOTCH1, NOTCH4 MYC 12/4885MAX 2554/4885MEN1 66/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.