Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 19/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.56 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1194341 | 0.88 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL1194189 | 0.87 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL4401457 | 0.87 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1193852 | 0.87 | PIK3CD (0.71) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL1194119 | 0.87 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL1194360 | 0.87 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL1194904 | 0.86 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL2688815 | 0.86 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1194302 | 0.85 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL1194959 | 0.84 | PIK3CD (0.72) | PIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168633-B2 | Thiazolopyrimidines and their use as inhibitors of phosphatidylinositol-3 kinase | GENENTECH, INC. (US) | 2012-05-01 | — | — | US | disclosed |