SCHEMBL26914980

SCHEMBL26914980

O=C(O)N1CCN2C(=O)c3ncc(C(F)(F)F)cc3OC[C@H]2C1

nearest known ligand 0.46

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TIPARP Q7Z3E1 18/20 0.46
PARP2 Q9UGN5 4/20 0.46
PARP1 P09874 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
PARP12 Q9H0J9 1/20 0.46
SCN9A Q15858 1/20 0.42
MDM2 Q00987 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26915142 1.00 TIPARP (0.46) TIPARPPARP2PARP1CYP2C9CYP2C19
SCHEMBL29841888 1.00 TIPARP (0.46) TIPARPPARP2PARP1CYP2C9CYP2C19
SCHEMBL26915033 0.88 TIPARP (0.54) TIPARPPARP2PARP1CYP2C9CYP2C19
SCHEMBL26914956 0.88 TIPARP (0.54) TIPARPPARP2PARP1CYP2C9CYP2C19
SCHEMBL29088940 0.88 TIPARP (0.54) TIPARPPARP2PARP1CYP2C9CYP2C19
SCHEMBL29841910 0.86 TIPARP (0.46) TIPARPPARP2PARP1CYP2C9CYP2C19
SCHEMBL29841921 0.86 TIPARP (0.46) TIPARPPARP2PARP1CYP2C9CYP2C19
SCHEMBL26915124 0.82 TIPARP (0.42) TIPARPPARP2PARP1CYP2C9CYP2C19
SCHEMBL29841861 0.80 TIPARP (0.39) TIPARPPARP2PARP1CYP2C9CYP2C19
SCHEMBL26914960 0.80 TIPARP (0.39) TIPARPPARP2PARP1CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4289845-A1 TRIHETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF Shanghai Apeiron Therapeutics Company Limited (CN) 2023-12-13 EP disclosed