Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 5/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30683028 | 1.00 | PLAU (0.36) | PLAUSLC6A4KDM1AL3MBTL1POLB | |
| SCHEMBL1621948 | 0.87 | RECQL (0.32) | RECQL | |
| SCHEMBL23292092 | 0.84 | EGFR (0.33) | EGFRERBB2ALDH1A1RECQLKMT2A | |
| SCHEMBL25873582 | 0.81 | PLAU (0.37) | PLAUSLC6A4KDM1AL3MBTL1POLB | |
| SCHEMBL29021806 | 0.80 | GRM5 (0.44) | L3MBTL1POLBALDH1A1MEN1KMT2A | |
| SCHEMBL4296773 | 0.80 | DYRK1B (0.36) | POLBALDH1A1MEN1KMT2A | |
| SCHEMBL17593337 | 0.79 | PLAU (0.42) | PLAUKDM1AL3MBTL1POLBEGFR | |
| SCHEMBL188937 | 0.79 | PIK3CA (0.37) | PLAUSLC6A4KDM1AL3MBTL1POLB | |
| SCHEMBL29812510 | 0.79 | PLAU (0.42) | PLAUKDM1AL3MBTL1POLBEGFR | |
| SCHEMBL3146860 | 0.79 | KMT2A (0.46) | PLAUKDM1APOLBPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023239645-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023239645-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |