Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 6/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26933939 | 0.86 | TACR1 (0.49) | TACR1GRIN1GRIN2BSIGMAR1BCHE | |
| SCHEMBL6042023 | 0.83 | TACR1 (0.57) | TACR1GRIN1GRIN2BSIGMAR1ACHE | |
| SCHEMBL6042019 | 0.83 | TACR1 (0.57) | TACR1GRIN1GRIN2BSIGMAR1ACHE | |
| SCHEMBL5870998 | 0.83 | TACR1 (0.59) | TACR1GRIN1GRIN2BSIGMAR1ALDH1A1 | |
| SCHEMBL12488908 | 0.82 | TACR1 (0.56) | TACR1GRIN1GRIN2BSIGMAR1S1PR1 | |
| SCHEMBL6041583 | 0.81 | TACR1 (0.61) | TACR1GRIN1GRIN2BSIGMAR1BCHE | |
| SCHEMBL1618266 | 0.81 | TACR1 (0.61) | TACR1GRIN1GRIN2BSIGMAR1BCHE | |
| SCHEMBL3545438 | 0.81 | TACR1 (0.54) | TACR1GRIN1GRIN2BSIGMAR1ALDH1A1 | |
| SCHEMBL1339508 | 0.80 | TACR1 (0.59) | TACR1GRIN1GRIN2BSIGMAR1ACHE | |
| SCHEMBL28164936 | 0.80 | TACR1 (0.59) | TACR1GRIN1GRIN2BSIGMAR1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250353863-A1 | TRICYCLIC SPIROLACTAM COMPOUNDS WITH ANTIMYCOBACTERIAL ACTIVITY | INST NAT SANTE RECH MED (FR) | 2025-11-20 | — | — | US | disclosed |
| EP-4536667-A1 | TRICYCLIC SPIROLACTAM COMPOUNDS WITH ANTIMYCOBACTERIAL ACTIVITY | Institut National de la Santé et de la Recherche Médicale (FR) | 2025-04-16 | — | — | EP | disclosed |
| WO-2023237580-A1 | TRICYCLIC SPIROLACTAM COMPOUNDS WITH ANTIMYCOBACTERIAL ACTIVITY | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023237580-A1 | TRICYCLIC SPIROLACTAM COMPOUNDS WITH ANTIMYCOBACTERIAL ACTIVITY | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 2023-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250353863-A1 | TRICYCLIC SPIROLACTAM COMPOUNDS WITH ANTIMYCOBACTERIAL ACTIVITY | TALDO1, TBCA, TBCD | TACR1 1620/4885GRIN1 4774/4885GRIN2B 4841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.