Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 18/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30780318 | 1.00 | TYK2 (0.43) | TYK2JAK2 | |
| SCHEMBL26983773 | 0.91 | TYK2 (0.43) | TYK2JAK2 | |
| SCHEMBL30780312 | 0.91 | TYK2 (0.43) | TYK2JAK2 | |
| SCHEMBL26983739 | 0.89 | TYK2 (0.57) | TYK2JAK2 | |
| SCHEMBL30780360 | 0.89 | TYK2 (0.57) | TYK2JAK2 | |
| SCHEMBL26991434 | 0.88 | TYK2 (0.43) | TYK2JAK2 | |
| SCHEMBL30780336 | 0.84 | TYK2 (0.36) | TYK2JAK2 | |
| SCHEMBL30780345 | 0.82 | TYK2 (0.44) | TYK2JAK2 | |
| SCHEMBL24784193 | 0.82 | JAK2 (0.52) | TYK2JAK2 | |
| SCHEMBL30780331 | 0.82 | TYK2 (0.36) | TYK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024010963-A1 | HETEROARYL COMPOUNDS AS INHIBITORS OF TYK2/JAK1, COMPOSITION AND APPLICATION THEREOF | ACCRO BIOSCIENCE (HK) LIMITED (CN) | 2024-01-11 | — | — | WO | disclosed |
| WO-2024010963-A1 | HETEROARYL COMPOUNDS AS INHIBITORS OF TYK2/JAK1, COMPOSITION AND APPLICATION THEREOF | ACCRO BIOSCIENCE (HK) LIMITED (CN) | 2024-01-11 | — | — | WO | disclosed |