Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 18/20 | 0.71 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.60 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2685889 | 0.91 | HDAC1 (0.77) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL2687141 | 0.86 | HDAC1 (0.76) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL5548289 | 0.86 | HDAC1 (0.69) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL2108006 | 0.83 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL5547680 | 0.83 | HDAC1 (0.71) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL3570726 | 0.81 | HDAC2 (0.53) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL2135459 | 0.79 | HDAC1 (0.65) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL2410081 | 0.79 | HDAC1 (0.78) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL1689286 | 0.78 | HDAC1 (0.74) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL3570455 | 0.78 | HDAC1 (0.51) | HDAC1HDAC2HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991226-B1 | INHIBITORS OF HISTONE DEACETYLASE | MERCK SHARP & DOHME (US) | 2013-03-20 | — | — | EP | claimed |
| EP-1991226-B1 | INHIBITORS OF HISTONE DEACETYLASE | MERCK SHARP & DOHME (US) | 2013-03-20 | — | — | EP | disclosed |
| US-8168658-B2 | Inhibitors of histone deacetylase | MERCK SHARP & DOHME CORP. (US) | 2012-05-01 | — | — | US | disclosed |