Ethionamide

Ethionamide

SCHEMBL27007

CCc1cc(C(N)=S)ccn1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

inhA

The experimentally established mechanism targets of Ethionamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 1.00
POLB P06746 1/20 1.00
KDM4E B2RXH2 1/20 0.77
LMNA P02545 1/20 0.77
CYP3A4 P08684 1/20 0.77
TSHR P16473 1/20 0.77
SMN1; SMN2 Q16637 1/20 0.46
PRKCI P41743 1/20 0.39
PROKR1 Q8TCW9 5/20 0.39
KDM5A P29375 1/20 0.36
KDM5C P41229 1/20 0.36
KDM5D Q9BY66 1/20 0.36
KDM4C Q9H3R0 1/20 0.36
KDM5B Q9UGL1 1/20 0.36
NOS3 P29474 1/20 0.36
NOS1 P29475 1/20 0.36
NOS2 P35228 1/20 0.36
MAP4K4 O95819 1/20 0.35
MBOAT4 Q96T53 1/20 0.35
SREBF1 P36956 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethionamide SCHEMBL788546 1.00 CYP1A2 (1.00) CYP1A2POLBKDM4ELMNACYP3A4
Ethionamide SCHEMBL12264093 1.00 CYP1A2 (1.00) CYP1A2POLBKDM4ELMNACYP3A4
Ethionamide SCHEMBL12264095 1.00 CYP1A2 (1.00) CYP1A2POLBKDM4ELMNACYP3A4
Ethionamide SCHEMBL29411271 1.00 CYP1A2 (1.00) CYP1A2POLBKDM4ELMNACYP3A4
Ethionamide SCHEMBL12264086 1.00 CYP1A2 (1.00) CYP1A2POLBKDM4ELMNACYP3A4
Ethionamide SCHEMBL12264085 1.00 CYP1A2 (1.00) CYP1A2POLBKDM4ELMNACYP3A4
Ethionamide SCHEMBL12264090 1.00 CYP1A2 (1.00) CYP1A2POLBKDM4ELMNACYP3A4
Ethionamide SCHEMBL12264091 1.00 CYP1A2 (1.00) CYP1A2POLBKDM4ELMNACYP3A4
Ethionamide SCHEMBL12264084 1.00 CYP1A2 (1.00) CYP1A2POLBKDM4ELMNACYP3A4
Ethionamide SCHEMBL15869612 0.98 CYP1A2 (0.96) CYP1A2POLBKDM4ELMNACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 42676 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6410577-B1 None US claimed
US-20260137766-A1 LIPOSOME FORMULATIONS FOR TREATMENT OF ACTIVE TUBERCULOSIS ARCHIVEL FARMA S L (ES) 2026-05-21 US claimed
CN-122032750-A Collector for floatation of mud-containing gangue molybdenum sulfide ore and floatation method 北矿化学科技(沧州)有限公司 2026-05-15 CN claimed
CN-122036001-A Oil-water separation method of magnetic mineral interface modification material in oilfield wastewater 中国石油化工股份有限公司 2026-05-15 CN claimed
EP-4736841-A1 A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT IQ medical GmbH (DE) 2026-05-06 EP claimed
US-12616691-B2 Use of fatty acid oxidation inhibitors as antimicrobials WASHINGTON UNIVERSITY IN ST. LOUIS (US) 2026-05-05 US claimed
EP-4727950-A1 HETEROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF MYCOBACTERIAL INFECTIONS GlaxoSmithKline Intellectual Property Development Ltd (GB) 2026-04-22 EP claimed
EP-4724049-A1 MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF Catalent Ontario Limited (CA) 2026-04-15 EP claimed
EP-4701639-A1 MOLECULES TARGETING INFECTED TISSUES AND METHODS OF USE THEREOF University of Tartu (EE) 2026-03-04 EP claimed
US-20260048047-A1 SMALL-MOLECULE ACTIVATORS OF MYCOBACTERIUM TUBERCULOSIS ADENYLYL CYCLASE SCRIPPS RESEARCH INST (US) 2026-02-19 US claimed
US-4096201-A BUTADIENE-ACRYLONITRILE COPOLYMER, HYDROXYALKYL METHACRYLATE, ALKYL METHACRYLATE, ORGANIC HYDROPEROXIDE DENKI KAGAKU KOGYO KABUSHIKI KAISHA (JA) 1978-06-20 US claimed
US-4080207-A Radiation-sensitive compositions and photographic elements containing N-(acylhydrazinophenyl) thioamide nucleating agents EASTMAN KODAK COMPANY (US) 1978-03-21 US claimed
US-4078002-A Reduction of chemical compounds with 9-BBN ALDRICH-BORANES, INC. (US) 1978-03-07 US claimed
US-4061497-A COBALTOUS SULFIDE, COLOR COUPLER, REDOX EASTMAN KODAK COMPANY (US) 1977-12-06 US claimed
US-4000159-A PREPARATION OF N,N-DISUBSTITUTED THIOAMIDES PHILLIPS PETROLEUM COMPANY (US) 1976-12-28 US claimed
US-3981883-A Manufacture of 3-amino-2,1-benzisothiazoles BASF AKTIENGESELLSCHAFT (DT) 1976-09-21 US claimed
US-3966945-A 2-Alkoxy(and 2-alkoxyalkyl)-2-heterocyclic-thioacetamides for inhibiting gastric acid secretion SMITHKLINE CORPORATION (US) 1976-06-29 US claimed
US-3959362-A Ammonium mercaptoalkanesulfonate salts, their preparation, photographic fixing solutions containing same, and method of fixing photographic film therewith EASTMAN KODAK COMPANY (US) 1976-05-25 US claimed
US-3956494-A ANTISECRETORY AGENTS, HETEROCYCLIC THIOPROPIONAMIDES SMITHKLINE CORPORATION (US) 1976-05-11 US claimed
US-3950522-A N-ALKENYL OR N-ALKYNYL THIOAMIDES SMITHKLINE CORPORATION (US) 1976-04-13 US claimed