Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.53 |
| ▸ | TP53 | P04637 | 6/20 | 0.53 |
| ▸ | HPGD | P15428 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.53 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.49 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30742078 | 1.00 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL26884886 | 1.00 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL24912684 | 0.87 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL26884771 | 0.86 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL27129922 | 0.86 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL27008503 | 0.83 | PIK3CA (0.65) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL27132077 | 0.83 | PIK3CA (0.65) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL26884767 | 0.82 | CYP1A1 (0.52) | PIK3CDPIK3CAPIK3CBPIK3CGMAPT | |
| SCHEMBL27130132 | 0.82 | CYP1A1 (0.52) | PIK3CDPIK3CAPIK3CBPIK3CGMAPT | |
| SCHEMBL24912995 | 0.81 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240018115-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | LOXO ONCOLOGY, INC. | 2024-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240018115-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | PIK3CA, PIK3R4, PIK3R5 | PIK3CD 6/4885PIK3CA 1/4885PIK3CB 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.