Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Benzamidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.76 |
| ▸ | F10 | P00742 | 1/20 | 0.76 |
| ▸ | F12 | P00748 | 1/20 | 0.76 |
| ▸ | F7 | P08709 | 1/20 | 0.76 |
| ▸ | F3 | P13726 | 1/20 | 0.76 |
| ▸ | PKM | P14618 | 1/20 | 0.76 |
| ▸ | BLM | P54132 | 2/20 | 0.73 |
| ▸ | RECQL | P46063 | 2/20 | 0.70 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.70 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.70 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.70 |
| ▸ | C1S | P09871 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | NQO2 | P16083 | 12/20 | 0.62 |
| ▸ | WDR5 | P61964 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzamidine SCHEMBL27925635 | 1.00 | F2 (0.76) | F2F10F12F7F3 | |
| Benzamidine SCHEMBL27844449 | 1.00 | F2 (0.76) | F2F10F12F7F3 | |
| Benzamidine SCHEMBL2781806 | 0.90 | F2 (0.84) | F2F10F12F7F3 | |
| Benzamidine SCHEMBL8983063 | 0.90 | F2 (0.84) | F2F10F12F7F3 | |
| Benzamidine SCHEMBL27322882 | 0.87 | F2 (0.89) | F2F10F12F7F3 | |
| Benzamidine SCHEMBL23067876 | 0.87 | F2 (1.00) | F2F10F12F7F3 | |
| Benzamidine SCHEMBL9207 | 0.87 | — | — | |
| Benzamidine SCHEMBL6013427 | 0.87 | F2 (0.64) | F2F10F12F7F3 | |
| SCHEMBL18557033 | 0.87 | F2 (1.00) | F2F10F12F7F3 | |
| Benzamidine SCHEMBL27781057 | 0.87 | F2 (1.00) | F2F10F12F7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1830955-A | Method for synthesizing O-ethoxy phenyl formamidine acetate | UNIV SHANDONG (CN) | 2006-09-13 | — | — | CN | claimed |
| EP-4327886-A2 | PYRIMIDO- PYRIDAZINONE COMPOUNDS AND USE THEREOF | Libertas Bio, Inc. (US) | 2024-02-28 | — | — | EP | disclosed |
| EP-3392252-B1 | PYRIMIDO- PYRIDAZINONE COMPOUNDS AND USE THEREOF | LIBERTAS BIO INC (US) | 2023-10-04 | — | — | EP | disclosed |
| CN-108707151-B | Pyrimido-pyridazinone compounds and uses thereof | 阿萨纳生物科技有限责任公司 | 2022-06-03 | — | — | CN | disclosed |
| US-20200190095-A1 | PYRIMIDO-PYRIDAZINONE COMPOUNDS AND METHODS OF USE THEREOF | ABS DEVELOPMENT 1, INC. | 2020-06-18 | — | — | US | disclosed |
| US-10647720-B2 | Pyrimido-pyridazinone compounds and methods of use thereof | Asan BioSciences, LLC (US) | 2020-05-12 | — | — | US | disclosed |
| US-20190092779-A1 | PYRIMIDO-PYRIDAZINONE COMPOUNDS AND METHODS OF USE THEREOF | Libertas Bio, Inc. | 2019-03-28 | — | — | US | disclosed |
| US-10183944-B2 | Pyrimido-pyridazinone compounds and methods of use thereof | ASANA BIOSCIENCES, LLC (US) | 2019-01-22 | — | — | US | disclosed |
| EP-3404029-A2 | PYRIMIDO-PYRIDAZINONE COMPOUNDS AND METHODS AND USE THEREOF | Asana BioSciences, LLC (US) | 2018-11-21 | — | — | EP | disclosed |
| EP-3392252-A1 | PYRIMIDO- PYRIDAZINONE COMPOUNDS AND USE THEREOF | Asana BioSciences, LLC (US) | 2018-10-24 | — | — | EP | disclosed |
| US-20070113930-A1 | Novel imidazole compound and use thereof | SHIKOKU CHEMICALS CORPORATION (JP) | 2007-05-24 | — | — | US | disclosed |
| EP-1753728-A1 | PHENYLNAPHTHYLIMIDAZOLES FOR USE ON COPPER SURFACES DURING SOLDERING | SHIKOKU CHEMICALS CORPORATION (JP) | 2007-02-21 | — | — | EP | disclosed |
| CN-1830955-A | Method for synthesizing O-ethoxy phenyl formamidine acetate | UNIV SHANDONG (CN) | 2006-09-13 | — | — | CN | disclosed |
| CN-1830955-A | Method for synthesizing O-ethoxy phenyl formamidine acetate | UNIV SHANDONG (CN) | 2006-09-13 | — | — | CN | disclosed |
| WO-2005121101-A1 | PHENYLNAPHTHYLIMIDAZOLES FOR USE ON COPPER SURFACES DURING SOLDERING | SHIKOKU CHEMICALS CORPORATION (JP) | 2005-12-22 | — | — | WO | disclosed |
| EP-1605078-A1 | NOVEL IMIDAZOLE COMPOUND AND USAGE THEREOF | SHIKOKU CHEMICALS CORPORATION (JP) | 2005-12-14 | — | — | EP | disclosed |
| CN-1642906-A | Novel arylamidine derivative or salt thereof | TOYAMA CHEMICAL CO LTD (JP) | 2005-07-20 | — | — | CN | disclosed |
| CN-1166633-C | New alpha-amino acid sulfuryl compounds, its preparing method and medicinal composition containing them | ɪά��ʵ���� | 2004-09-15 | — | — | CN | disclosed |
| CN-1377879-A | New alpha-amino acid sulfuryl compounds, its preparing method and medicinal composition containing them | SEWIL LAB (FR) | 2002-11-06 | — | — | CN | disclosed |
| CN-1272107-A | Benzamidine derivatives as factor Xa inhibitors | MERCK PATENT GMBH (DE) | 2000-11-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10183944-B2 | Pyrimido-pyridazinone compounds and methods of use thereof | THPO, TYMP, TYMS | F2 391/4885F10 2794/4885F12 1478/4885 |
| US-20190092779-A1 | PYRIMIDO-PYRIDAZINONE COMPOUNDS AND METHODS OF USE THEREOF | THPO, TYMP, TYMS | F2 391/4885F10 2794/4885F12 1478/4885 |
| US-20200190095-A1 | PYRIMIDO-PYRIDAZINONE COMPOUNDS AND METHODS OF USE THEREOF | THPO, TYMP, TYMS | F2 391/4885F10 2794/4885F12 1478/4885 |
| US-10647720-B2 | Pyrimido-pyridazinone compounds and methods of use thereof | THPO, TYMP, TYMS | F2 391/4885F10 2794/4885F12 1478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.