Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.42 |
| ▸ | JAK1 | P23458 | 11/20 | 0.42 |
| ▸ | TYK2 | P29597 | 7/20 | 0.42 |
| ▸ | JAK3 | P52333 | 7/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | BMP4 | P12644 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29958618 | 1.00 | JAK2 (0.42) | JAK2JAK1TYK2JAK3IRAK4 | |
| SCHEMBL27028676 | 0.90 | IRAK4 (0.45) | JAK2JAK1TYK2JAK3IRAK4 | |
| SCHEMBL29958611 | 0.90 | IRAK4 (0.45) | JAK2JAK1TYK2JAK3IRAK4 | |
| SCHEMBL29958828 | 0.85 | IRAK4 (0.46) | JAK2JAK1TYK2JAK3IRAK4 | |
| SCHEMBL27028659 | 0.85 | IRAK4 (0.46) | JAK2JAK1TYK2JAK3IRAK4 | |
| SCHEMBL27028805 | 0.84 | JAK2 (0.42) | JAK2JAK1TYK2JAK3IRAK4 | |
| SCHEMBL29958736 | 0.83 | IRAK4 (0.44) | JAK2JAK1TYK2JAK3IRAK4 | |
| SCHEMBL27028770 | 0.83 | JAK2 (0.44) | JAK2JAK1TYK2JAK3IRAK4 | |
| SCHEMBL27028607 | 0.83 | IRAK4 (0.44) | JAK2JAK1TYK2JAK3IRAK4 | |
| SCHEMBL29958601 | 0.81 | IRAK4 (0.44) | JAK2JAK1TYK2JAK3IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308122-A1 | HETEROCYCLIC DERIVATIVES AS JANUS KINASE INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2024-01-24 | — | — | EP | claimed |