Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.35 |
| ▸ | CLK2 | P49760 | 2/20 | 0.35 |
| ▸ | CLK3 | P49761 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.31 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.31 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.31 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.31 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | FER | P16591 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29925477 | 1.00 | GSK3B (0.35) | GSK3BDYRK1ACLK2CLK3NTRK1 | |
| SCHEMBL29925226 | 0.88 | GSK3B (0.37) | GSK3BDYRK1ACLK2CLK3HTR2A | |
| SCHEMBL27031818 | 0.88 | GSK3B (0.37) | GSK3BDYRK1ACLK2CLK3HTR2A | |
| SCHEMBL27031770 | 0.88 | MAP2K4 (0.38) | GSK3BDYRK1ACLK2CLK3LRRK2 | |
| SCHEMBL27031905 | 0.88 | DYRK1A (0.38) | GSK3BDYRK1ACLK2CLK3HTR2A | |
| SCHEMBL29925821 | 0.87 | MAP2K4 (0.38) | GSK3BDYRK1ACLK2CLK3LRRK2 | |
| SCHEMBL27031755 | 0.87 | MAP2K4 (0.38) | GSK3BDYRK1ACLK2CLK3LRRK2 | |
| SCHEMBL29925328 | 0.86 | GSK3B (0.44) | GSK3BDYRK1ACLK2CLK3MAPK1 | |
| SCHEMBL27032504 | 0.86 | GSK3B (0.44) | GSK3BDYRK1ACLK2CLK3MAPK1 | |
| SCHEMBL29925556 | 0.84 | GSK3B (0.35) | GSK3BDYRK1ACLK2CLK3NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308570-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | Les Laboratoires Servier (FR) | 2024-01-24 | — | — | EP | claimed |
| EP-4308570-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | Les Laboratoires Servier (FR) | 2024-01-24 | — | — | EP | disclosed |