Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.46 |
| ▸ | CLK2 | P49760 | 4/20 | 0.46 |
| ▸ | CLK3 | P49761 | 3/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.36 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | FER | P16591 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MARK3 | P27448 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29925758 | 1.00 | GSK3B (0.46) | GSK3BDYRK1ACLK2CLK3IRAK4 | |
| SCHEMBL29925229 | 0.86 | GSK3B (0.46) | GSK3BDYRK1ACLK2CLK3MAP2K4 | |
| SCHEMBL29925276 | 0.86 | GSK3B (0.48) | GSK3BDYRK1ACLK2CLK3IRAK4 | |
| SCHEMBL27031794 | 0.86 | GSK3B (0.48) | GSK3BDYRK1ACLK2CLK3IRAK4 | |
| SCHEMBL29925556 | 0.85 | GSK3B (0.35) | GSK3BDYRK1ACLK2CLK3IRAK4 | |
| SCHEMBL24012463 | 0.85 | GSK3B (0.40) | GSK3BDYRK1ACLK2CLK3IRAK4 | |
| SCHEMBL30242524 | 0.85 | GSK3B (0.40) | GSK3BDYRK1ACLK2CLK3IRAK4 | |
| SCHEMBL27032504 | 0.85 | GSK3B (0.44) | GSK3BDYRK1ACLK2CLK3IRAK4 | |
| SCHEMBL29925328 | 0.85 | GSK3B (0.44) | GSK3BDYRK1ACLK2CLK3IRAK4 | |
| SCHEMBL30242465 | 0.82 | GSK3B (0.41) | GSK3BDYRK1ACLK2CLK3IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308570-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | Les Laboratoires Servier (FR) | 2024-01-24 | — | — | EP | claimed |
| EP-4308570-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | Les Laboratoires Servier (FR) | 2024-01-24 | — | — | EP | disclosed |