Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 4/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27133812 | 1.00 | SCN4A (0.48) | SCN4APOLBAKT1TACR1PDPK1 | |
| SCHEMBL29829839 | 0.90 | SCN4A (0.46) | SCN4APOLBAKT1TACR1 | |
| SCHEMBL27129114 | 0.89 | SCN4A (0.51) | SCN4AAKT1TACR1PDPK1RPS6KB1 | |
| SCHEMBL27032707 | 0.89 | SCN4A (0.51) | SCN4AAKT1TACR1PDPK1RPS6KB1 | |
| SCHEMBL27032942 | 0.82 | SCN4A (0.51) | SCN4AAKT1TACR1RPS6KB1 | |
| SCHEMBL27131661 | 0.82 | SCN4A (0.51) | SCN4AAKT1TACR1RPS6KB1 | |
| SCHEMBL29828802 | 0.80 | SCN4A (0.46) | SCN4ATACR1 | |
| SCHEMBL29096821 | 0.80 | SCN4A (0.46) | SCN4ATACR1 | |
| SCHEMBL29096825 | 0.80 | SCN4A (0.46) | SCN4ATACR1 | |
| Hydrochloric Acid SCHEMBL27032989 | 0.79 | SCN4A (0.50) | SCN4APOLBAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240208992-A1 | MACROCYCLES AS CFTR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2024-06-27 | — | — | US | disclosed |
| EP-4308575-A1 | MACROCYCLES AS CFTR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2024-01-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240208992-A1 | MACROCYCLES AS CFTR MODULATORS | CFTR, PKD1, ARRB1 | SCN4A 424/4885POLB 3290/4885AKT1 1808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.