Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.41 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29828542 | 1.00 | AAK1 (0.41) | AAK1RENMMP13 | |
| SCHEMBL27032866 | 0.89 | AAK1 (0.40) | AAK1RENMMP13 | |
| SCHEMBL27032815 | 0.89 | AAK1 (0.42) | AAK1RENMMP13 | |
| SCHEMBL27130846 | 0.89 | AAK1 (0.40) | AAK1RENMMP13 | |
| SCHEMBL29097004 | 0.89 | AAK1 (0.42) | AAK1RENMMP13 | |
| SCHEMBL29828824 | 0.89 | AAK1 (0.42) | AAK1RENMMP13 | |
| SCHEMBL30916053 | 0.87 | AAK1 (0.41) | AAK1RENMMP13 | |
| SCHEMBL30916086 | 0.86 | AAK1 (0.40) | AAK1RENMMP13 | |
| SCHEMBL23005858 | 0.84 | AAK1 (0.49) | AAK1RENMMP13 | |
| SCHEMBL24093716 | 0.84 | AAK1 (0.49) | AAK1RENMMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240208992-A1 | MACROCYCLES AS CFTR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2024-06-27 | — | — | US | disclosed |
| EP-4308575-A1 | MACROCYCLES AS CFTR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2024-01-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240208992-A1 | MACROCYCLES AS CFTR MODULATORS | CFTR, PKD1, ARRB1 | AAK1 2340/4885REN 537/4885MMP13 4679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.