Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
| ▸ | P4HB | P07237 | 1/20 | 0.40 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.39 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.39 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12023132 | 0.82 | AOC3 (0.53) | AOC3CYP3A4TXNRD1TXNRD3TXNRD2 | |
| SCHEMBL767958 | 0.78 | AOC3 (0.50) | AOC3CYP3A4TXNRD1TXNRD3TXNRD2 | |
| SCHEMBL25981475 | 0.78 | AOC3 (0.54) | AOC3CYP3A4P4HBTXNRD1TXNRD3 | |
| SCHEMBL4493536 | 0.78 | AOC3 (0.50) | AOC3CYP3A4P4HBTXNRD1TXNRD3 | |
| SCHEMBL767702 | 0.78 | AOC3 (0.50) | AOC3CYP3A4TXNRD1TXNRD3TXNRD2 | |
| SCHEMBL12613198 | 0.78 | AOC3 (0.42) | AOC3CYP3A4P4HBTXNRD1TXNRD3 | |
| SCHEMBL12119917 | 0.78 | NQO2 (0.44) | AOC3CYP3A4P4HBTXNRD1TXNRD3 | |
| SCHEMBL10430741 | 0.75 | ERN1 (0.44) | AOC3CYP3A4P4HBTXNRD1TXNRD3 | |
| SCHEMBL12023063 | 0.75 | AOC3 (0.47) | AOC3CYP3A4TXNRD1TXNRD3TXNRD2 | |
| SCHEMBL11086762 | 0.75 | AOC3 (0.65) | AOC3CYP3A4TXNRD1TXNRD3TXNRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240208992-A1 | MACROCYCLES AS CFTR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2024-06-27 | — | — | US | disclosed |
| EP-4308575-A1 | MACROCYCLES AS CFTR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2024-01-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240208992-A1 | MACROCYCLES AS CFTR MODULATORS | CFTR, PKD1, ARRB1 | AOC3 3106/4885CYP3A4 1162/4885PSMB5 1494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.