Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 4/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27131394 | 1.00 | CD274 (0.36) | CD274PDCD1CSF1RIRAK4KCNA5 | |
| SCHEMBL29983594 | 0.89 | PRMT5 (0.38) | CD274PDCD1CSF1RIRAK4KCNA5 | |
| SCHEMBL27081011 | 0.87 | PDCD1 (0.33) | CD274PDCD1CSF1RIRAK4KCNA5 | |
| SCHEMBL27082143 | 0.83 | CD274 (0.39) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL27082149 | 0.83 | CD274 (0.39) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL27147971 | 0.81 | CD274 (0.40) | CD274PDCD1IRAK4KCNA5MAPK1 | |
| SCHEMBL27036518 | 0.81 | CD274 (0.40) | CD274PDCD1IRAK4KCNA5MAPK1 | |
| SCHEMBL23726312 | 0.76 | CD274 (0.51) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL23200203 | 0.75 | AAK1 (0.38) | KCNA5BACE1 | |
| SCHEMBL23727266 | 0.74 | CD274 (0.54) | CD274PDCD1PDCD1LG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024134466-A1 | SUBSTITUTED ARYLAMINE COMPOUNDS, SUBSTITUTED HETEROARYLAMINE COMPOUNDS, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2024-06-27 | — | — | WO | disclosed |
| WO-2024069448-A1 | SUBSTITUTED 1-ARYLAMINOCARBONYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1-HETEROARYLAMINOCARBONYL-1'-HETEROARYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2024-04-04 | — | — | WO | disclosed |
| EP-4313968-A2 | SUBSTITUTED 1-ARYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1,1'-BIHETEROARYL COMPOUNDS, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2024-02-07 | — | — | EP | disclosed |
| WO-2024018403-A1 | SUBSTITUTED IMIDAZOAMIDE COMPOUNDS, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2024-01-25 | — | — | WO | disclosed |