Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 18/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 16/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27225072 | 0.89 | POLB (0.41) | POLBCRBNDDB1ALDH1A1HPGD | |
| SCHEMBL27041829 | 0.82 | CRBN (0.38) | CRBNDDB1 | |
| SCHEMBL31727134 | 0.82 | CRBN (0.42) | POLBCRBNDDB1 | |
| SCHEMBL30831059 | 0.81 | CRBN (0.46) | CRBNDDB1ALDH1A1MAPK1 | |
| SCHEMBL26641367 | 0.79 | CRBN (0.39) | POLBCRBNDDB1 | |
| SCHEMBL31070352 | 0.78 | CRBN (0.48) | POLBCRBNDDB1 | |
| SCHEMBL27224918 | 0.77 | CRBN (0.41) | POLBCRBNDDB1ALDH1A1 | |
| SCHEMBL26641298 | 0.77 | CRBN (0.56) | CRBNDDB1 | |
| SCHEMBL30830796 | 0.77 | DDB1 (0.53) | CRBNDDB1 | |
| SCHEMBL31727584 | 0.76 | DDB1 (0.52) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024020522-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF IRAK-4 | ARVINAS OPERATIONS, INC. (US) | 2024-01-25 | — | — | WO | disclosed |
| WO-2024020522-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF IRAK-4 | ARVINAS OPERATIONS, INC. (US) | 2024-01-25 | — | — | WO | disclosed |