Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.85 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.85 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.85 |
| ▸ | PLK1 | P53350 | 3/20 | 0.85 |
| ▸ | PLK4 | O00444 | 2/20 | 0.85 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.85 |
| ▸ | ABL1 | P00519 | 2/20 | 0.85 |
| ▸ | EGFR | P00533 | 2/20 | 0.85 |
| ▸ | LCK | P06239 | 2/20 | 0.85 |
| ▸ | HCK | P08631 | 2/20 | 0.85 |
| ▸ | ROS1 | P08922 | 2/20 | 0.85 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.85 |
| ▸ | SRC | P12931 | 2/20 | 0.85 |
| ▸ | FER | P16591 | 2/20 | 0.85 |
| ▸ | FLT1 | P17948 | 2/20 | 0.85 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.85 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.85 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.85 |
| ▸ | GRK5 | P34947 | 2/20 | 0.85 |
| ▸ | KDR | P35968 | 2/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10239212 | 0.93 | AURKA (0.77) | AURKAAURKBGABRA1PLK1PLK4 | |
| SCHEMBL16602406 | 0.93 | AURKA (0.88) | AURKAAURKBGABRA1PLK1PLK4 | |
| Mln-8054 SCHEMBL621589 | 0.92 | AURKA (1.00) | AURKAAURKBGABRA1PLK1PLK4 | |
| Mln-8054 SCHEMBL29372555 | 0.92 | AURKA (1.00) | AURKAAURKBGABRA1PLK1PLK4 | |
| Mln-8054 SCHEMBL29720492 | 0.92 | AURKA (1.00) | AURKAAURKBGABRA1PLK1PLK4 | |
| SCHEMBL2704890 | 0.92 | AURKA (0.83) | AURKAAURKBGABRA1PLK1PLK4 | |
| SCHEMBL2704222 | 0.91 | AURKA (0.85) | AURKAAURKBGABRA1PLK1PLK4 | |
| SCHEMBL2705102 | 0.91 | AURKA (0.84) | AURKAAURKBGABRA1PLK1PLK4 | |
| SCHEMBL2705466 | 0.89 | AURKA (0.81) | AURKAAURKBGABRA1PLK1PLK4 | |
| SCHEMBL26005096 | 0.89 | AURKA (0.84) | AURKAAURKBGABRA1PLK1PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240083906-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | MILLENNIUM PHARM INC (US) | 2024-03-14 | — | — | US | disclosed |
| US-20220041605-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | MILLENNIUM PHARMACEUTICALS, INC. | 2022-02-10 | — | — | US | disclosed |
| US-11014928-B2 | Compounds and methods for inhibiting mitotic progression | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2021-05-25 | — | — | US | disclosed |
| US-11014928-B2 | Compounds and methods for inhibiting mitotic progression | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2021-05-25 | — | — | US | disclosed |
| EP-2713727-B1 | COMBINATION OF MEK INHIBITORS AND SELECTIVE INHIBITORS OF AURORA A KINASE | MILLENNIUM PHARM INC (US) | 2021-03-31 | — | — | EP | disclosed |
| EP-3317427-B1 | BIOMARKERS OF RESPONSE TO SELECTIVE INHIBITORS OF AURORA A KINASE | MILLENNIUM PHARM INC (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-2976086-B1 | COMBINATION OF CATALYTIC MTORC 1/2 INHIBITORS AND SELECTIVE INHIBITORS OF AURORA A KINASE | MILLENNIUM PHARM INC (US) | 2020-10-14 | — | — | EP | disclosed |
| US-20200247810-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | MILLENNIUM PHARMACEUTICALS, INC. | 2020-08-06 | — | — | US | disclosed |
| US-20200247810-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | MILLENNIUM PHARMACEUTICALS, INC. | 2020-08-06 | — | — | US | disclosed |
| US-10414770-B2 | Compounds and methods for inhibiting mitotic progression | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2019-09-17 | — | — | US | disclosed |
| US-20090299060-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-12-03 | — | — | US | disclosed |
| US-7572784-B2 | Compounds and methods for inhibiting mitotic progression | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-08-11 | — | — | US | disclosed |
| US-7572784-B2 | Compounds and methods for inhibiting mitotic progression | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-08-11 | — | — | US | disclosed |
| US-7572784-B2 | Compounds and methods for inhibiting mitotic progression | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-08-11 | — | — | US | disclosed |
| EP-1771450-B9 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION BY INHIBITION OF AURORA KINASE | MILLENNIUM PHARM INC (US) | 2008-12-24 | — | — | EP | disclosed |
| EP-1905773-A2 | Compounds and methods for inhibiting mitotic progression by inhibition of aurora kinase | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-04-02 | — | — | EP | disclosed |
| EP-1771450-B1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION BY INHIBITION OF AURORA KINASE | MILLENNIUM PHARM INC (US) | 2007-12-19 | — | — | EP | disclosed |
| US-20070185087-A1 | Compounds and methods for inhibiting mitotic progression | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-08-09 | — | — | US | disclosed |
| US-20070185087-A1 | Compounds and methods for inhibiting mitotic progression | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-08-09 | — | — | US | disclosed |
| US-20050256102-A1 | Compounds and methods for inhibiting mitotic progression | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247810-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | AURKC, AURKA, AURKB | AURKA 2/4885AURKB 3/4885GABRA1 4822/4885 |
| US-20050256102-A1 | Compounds and methods for inhibiting mitotic progression | AURKC, AURKA, AURKB | AURKA 2/4885AURKB 3/4885GABRA1 4822/4885 |
| US-20070185087-A1 | Compounds and methods for inhibiting mitotic progression | AURKC, AURKA, AURKB | AURKA 2/4885AURKB 3/4885GABRA1 4822/4885 |
| US-10414770-B2 | Compounds and methods for inhibiting mitotic progression | AURKC, AURKA, AURKB | AURKA 2/4885AURKB 3/4885GABRA1 4822/4885 |
| US-11014928-B2 | Compounds and methods for inhibiting mitotic progression | AURKC, AURKA, AURKB | AURKA 2/4885AURKB 3/4885GABRA1 4822/4885 |
| US-20090299060-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | AURKC, AURKA, AURKB | AURKA 2/4885AURKB 3/4885GABRA1 4822/4885 |
| US-20220041605-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | AURKC, AURKA, AURKB | AURKA 2/4885AURKB 3/4885GABRA1 4822/4885 |
| US-20240083906-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | AURKC, AURKA, AURKB | AURKA 2/4885AURKB 3/4885GABRA1 4822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.