Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 18/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 18/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 17/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 16/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 12/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 11/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 11/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 11/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 11/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2704501 | 1.00 | HDAC1 (0.37) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL10072100 | 0.84 | HDAC4 (0.38) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL2707021 | 0.84 | HDAC3 (0.43) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL2707017 | 0.84 | HDAC3 (0.43) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL10072245 | 0.83 | HDAC1 (0.34) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL7899095 | 0.79 | HDAC3 (0.46) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL9895121 | 0.79 | HDAC3 (0.46) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL181811 | 0.78 | HDAC4 (0.40) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL181812 | 0.78 | HDAC4 (0.40) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL181679 | 0.77 | HDAC3 (0.41) | HDAC1HDAC3HDAC8HDAC6HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012025701-A1 | ALPHA, ALPHA - DI SUBSTITUTED GLYCINE ESTER DERIVATIVES AND THEIR USE AS HDAC INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2012-03-01 | — | — | WO | disclosed |