Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SCN4A | P35499 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27052005 | 0.85 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL27051978 | 0.84 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL27051986 | 0.81 | HSD17B10 (0.42) | SMN1; SMN2ALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL27051994 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL27051971 | 0.75 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL27051993 | 0.75 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL27052004 | 0.73 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL27051907 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL27051980 | 0.73 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL27051748 | 0.71 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1TP53CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025918-A1 | KRAS G12D Inhibitors | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2024-01-25 | — | — | US | disclosed |
| US-20240025918-A1 | KRAS G12D Inhibitors | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2024-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240025918-A1 | KRAS G12D Inhibitors | KRAS, NRAS, HRAS | SMN1; SMN2 3857/4885ALDH1A1 3208/4885TP53 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.