Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | SCN4A | P35499 | 3/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | MPL | P40238 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27051989 | 0.88 | HSD17B10 (0.44) | HSD17B10HPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL27051991 | 0.87 | HSD17B10 (0.43) | HSD17B10HPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL27051986 | 0.85 | HSD17B10 (0.42) | HSD17B10HPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL27052015 | 0.85 | HSD17B10 (0.42) | HSD17B10HPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL27051987 | 0.84 | HPGD (0.41) | HSD17B10HPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL27052016 | 0.83 | HSD17B10 (0.40) | HSD17B10HPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL27051981 | 0.79 | SMN1; SMN2 (0.40) | HSD17B10HPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL27051971 | 0.79 | SMN1; SMN2 (0.46) | HSD17B10HPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL27052011 | 0.78 | SMN1; SMN2 (0.39) | HSD17B10HPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL27052004 | 0.78 | SMN1; SMN2 (0.46) | SMN1; SMN2RAB9ANPC1SCN4ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025918-A1 | KRAS G12D Inhibitors | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2024-01-25 | — | — | US | disclosed |
| US-20240025918-A1 | KRAS G12D Inhibitors | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2024-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240025918-A1 | KRAS G12D Inhibitors | KRAS, NRAS, HRAS | HSD17B10 3313/4885HPGD 397/4885SMN1; SMN2 3857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.