SCHEMBL2705892

SCHEMBL2705892

O=C(C=Cc1ccc(CNC2(C(=O)OC3CCCC3)CCOCC2)nc1)NO

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 8/20 0.41
HDAC6 Q9UBN7 7/20 0.41
CDK9 P50750 1/20 0.41
HDAC4 P56524 8/20 0.40
MEF2D Q14814 4/20 0.40
HDAC1 Q13547 12/20 0.39
HDAC8 Q9BY41 8/20 0.39
HDAC5 Q9UQL6 4/20 0.39
HDAC2 Q92769 8/20 0.36
HDAC7 Q8WUI4 3/20 0.36
HDAC10 Q969S8 3/20 0.36
HDAC11 Q96DB2 3/20 0.36
HDAC9 Q9UKV0 3/20 0.36
CYP1A2 P05177 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2705886 1.00 HDAC3 (0.41) HDAC3HDAC6CDK9HDAC4MEF2D
SCHEMBL2731939 0.93 HDAC4 (0.43) HDAC3HDAC6CDK9HDAC4MEF2D
SCHEMBL2704493 0.93 HDAC4 (0.43) HDAC3HDAC6CDK9HDAC4MEF2D
SCHEMBL2706516 0.93 HDAC4 (0.42) HDAC3HDAC6CDK9HDAC4MEF2D
SCHEMBL2705913 0.93 HDAC4 (0.42) HDAC3HDAC6CDK9HDAC4MEF2D
SCHEMBL2706520 0.93 HDAC4 (0.42) HDAC3HDAC6CDK9HDAC4MEF2D
SCHEMBL2705917 0.93 HDAC4 (0.42) HDAC3HDAC6CDK9HDAC4MEF2D
SCHEMBL2705554 0.92 HDAC1 (0.43) HDAC3HDAC6CDK9HDAC4MEF2D
SCHEMBL2705556 0.92 HDAC1 (0.43) HDAC3HDAC6CDK9HDAC4MEF2D
SCHEMBL2704435 0.88 HDAC3 (0.50) HDAC3HDAC6HDAC4MEF2DHDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012025701-A1 ALPHA, ALPHA - DI SUBSTITUTED GLYCINE ESTER DERIVATIVES AND THEIR USE AS HDAC INHIBITORS CHROMA THERAPEUTICS LTD. (GB) 2012-03-01 WO claimed
WO-2012025701-A1 ALPHA, ALPHA - DI SUBSTITUTED GLYCINE ESTER DERIVATIVES AND THEIR USE AS HDAC INHIBITORS CHROMA THERAPEUTICS LTD. (GB) 2012-03-01 WO disclosed
WO-2012025701-A1 ALPHA, ALPHA - DI SUBSTITUTED GLYCINE ESTER DERIVATIVES AND THEIR USE AS HDAC INHIBITORS CHROMA THERAPEUTICS LTD. (GB) 2012-03-01 WO disclosed