SCHEMBL27067896

SCHEMBL27067896

CC1CC(c2cccc(-n3cc(C4CC4)c4cc[nH]c4c3=O)c2)(c2nncn2C)C1

nearest known ligand 0.55

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ CBLB Q13191 20/20 0.55
▸ CBL P22681 17/20 0.55
▸ CBLC Q9ULV8 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32666757 1.00 CBLB (0.55) CBLBCBLCBLC
SCHEMBL27041304 0.91 CBLB (0.44) CBLBCBL
SCHEMBL30728181 0.89 CBLB (0.43) CBLBCBL
SCHEMBL27067954 0.89 CBLB (0.58) CBLBCBLCBLC
SCHEMBL27067961 0.89 CBLB (0.64) CBLBCBLCBLC
SCHEMBL32666683 0.89 CBLB (0.64) CBLBCBLCBLC
SCHEMBL32666752 0.89 CBLB (0.55) CBLBCBL
SCHEMBL27067917 0.88 CBLB (0.55) CBLBCBLCBLC
SCHEMBL32666984 0.87 CBLB (0.55) CBLBCBLCBLC
SCHEMBL27068203 0.87 CBLB (0.55) CBLBCBLCBLC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024020034-A1 CBL-B INHIBITORS AND METHODS OF USE THEREOF ARCUS BIOSCIENCES, INC. (US) 2024-01-25 — — WO disclosed
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