SCHEMBL27068006

SCHEMBL27068006

CC1CC(c2cccc(-n3cc(C4CC4)c4cc(CN5CCCC[C@@H]5C)[nH]c4c3=O)c2)(c2nncn2C)C1

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ CBLB Q13191 20/20 0.48
▸ CBL P22681 15/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27067894 0.91 CBLB (0.49) CBLBCBL
SCHEMBL27067893 0.91 CBLB (0.49) CBLBCBL
SCHEMBL27068964 0.90 CBLB (0.46) CBLBCBL
SCHEMBL27069026 0.88 CBLB (0.49) CBLBCBL
SCHEMBL27041326 0.88 CBLB (0.52) CBLBCBL
SCHEMBL30728178 0.88 CBLB (0.54) CBLBCBL
SCHEMBL27068036 0.88 CBLB (0.49) CBLBCBL
SCHEMBL27068064 0.87 CBLB (0.47) CBLBCBL
SCHEMBL27068061 0.87 CBLB (0.51) CBLBCBL
SCHEMBL27068041 0.87 CBLB (0.51) CBLBCBL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024020034-A1 CBL-B INHIBITORS AND METHODS OF USE THEREOF ARCUS BIOSCIENCES, INC. (US) 2024-01-25 — — WO disclosed
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