Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 16/20 | 0.46 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.42 |
| ▸ | DLK1 | P80370 | 1/20 | 0.42 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27072976 | 0.75 | MAP3K12 (0.41) | MAP3K12DLK1 | |
| SCHEMBL25147712 | 0.74 | MAP3K12 (0.50) | MAP3K12MAP3K13DLK1MAP3K7 | |
| SCHEMBL15743911 | 0.74 | MAP3K12 (0.50) | MAP3K12MAP3K13DLK1MAP3K7 | |
| SCHEMBL15743920 | 0.74 | MAP3K12 (0.50) | MAP3K12MAP3K13DLK1MAP3K7 | |
| SCHEMBL25986253 | 0.72 | NTRK1 (0.45) | — | |
| SCHEMBL23807999 | 0.72 | NTRK1 (0.45) | — | |
| SCHEMBL23807996 | 0.72 | NTRK1 (0.45) | — | |
| SCHEMBL23945834 | 0.70 | IRAK4 (0.46) | — | |
| SCHEMBL21997814 | 0.70 | IRAK4 (0.46) | — | |
| SCHEMBL21996976 | 0.70 | IRAK4 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024020084-A1 | HETEROARYL COMPOUNDS AS LIGAND DIRECTED DEGRADERS OF IRAK4 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-01-25 | — | — | WO | disclosed |