Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 15/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2711565 | 0.92 | MTOR (0.43) | MTORPIK3CAALDH1A1HPGDHIF1A | |
| SCHEMBL2708261 | 0.83 | PIK3CA (0.49) | MTORPIK3CAPIK3CDPIK3CG | |
| SCHEMBL2726275 | 0.82 | MTOR (0.51) | MTORPIK3CAPIK3CDPIK3CG | |
| SCHEMBL2728259 | 0.81 | MTOR (0.47) | MTORPIK3CAHIF1APIK3CDPIK3CG | |
| SCHEMBL2707460 | 0.80 | PIK3CA (0.60) | MTORPIK3CAPIK3CDPIK3CG | |
| SCHEMBL985243 | 0.79 | MTOR (0.51) | MTORALDH1A1HIF1A | |
| SCHEMBL2708734 | 0.79 | MTOR (0.42) | MTORPIK3CAHIF1APIK3CDPIK3CG | |
| SCHEMBL2727127 | 0.79 | GRIA1 (0.47) | MTORPIK3CAALDH1A1HIF1APIK3CD | |
| SCHEMBL2709295 | 0.78 | MTOR (0.57) | MTORPIK3CAPIK3CDPIK3CG | |
| SCHEMBL2707251 | 0.77 | MTOR (0.42) | MTORPIK3CAHIF1APIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445346-A1 | OXO-HETEROCYCLE FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Genentech, Inc. (US) | 2012-05-02 | — | — | EP | claimed |
| WO-2010151601-A1 | OXO-HETEROCYCLE FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-12-29 | — | — | WO | claimed |