Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 8/20 | 0.72 |
| ▸ | MERTK | Q12866 | 6/20 | 0.72 |
| ▸ | TYRO3 | Q06418 | 15/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28662081 | 0.93 | TYRO3 (0.71) | AXLMERTKTYRO3 | |
| SCHEMBL28671134 | 0.92 | TYRO3 (0.69) | AXLMERTKTYRO3 | |
| SCHEMBL29626112 | 0.91 | AXL (0.70) | AXLMERTKTYRO3 | |
| SCHEMBL29626159 | 0.89 | TYRO3 (0.71) | AXLMERTKTYRO3 | |
| SCHEMBL29626196 | 0.89 | TYRO3 (0.69) | AXLMERTKTYRO3 | |
| SCHEMBL29626246 | 0.89 | TYRO3 (0.69) | AXLMERTKTYRO3 | |
| SCHEMBL28688286 | 0.87 | TYRO3 (0.64) | AXLMERTKTYRO3 | |
| SCHEMBL28671123 | 0.87 | TYRO3 (0.71) | AXLMERTKTYRO3 | |
| SCHEMBL29626168 | 0.87 | AXL (0.70) | AXLMERTKTYRO3 | |
| SCHEMBL29626133 | 0.87 | TYRO3 (0.70) | AXLMERTKTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114456175-B | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2024-09-03 | — | — | CN | disclosed |
| CN-114456176-B | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2024-08-30 | — | — | CN | disclosed |
| EP-4321513-A2 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | Incyte Corporation (US) | 2024-02-14 | — | — | EP | disclosed |
| CN-114456175-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-114456176-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-109348715-B | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2021-12-31 | — | — | CN | disclosed |