Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27097534 | 1.00 | HRH3 (0.43) | HRH3NPC1ALDH1A1KCNH2KDM4E | |
| SCHEMBL27097472 | 0.89 | NPC1 (0.55) | HRH3NPC1ALDH1A1CYP2D6 | |
| SCHEMBL27097577 | 0.89 | NPC1 (0.55) | HRH3NPC1ALDH1A1CYP2D6 | |
| SCHEMBL26016378 | 0.80 | HRH3 (0.42) | HRH3NPC1 | |
| SCHEMBL26016376 | 0.80 | HRH3 (0.42) | HRH3NPC1 | |
| SCHEMBL26016383 | 0.75 | HRH3 (0.44) | HRH3NPC1 | |
| SCHEMBL27097601 | 0.74 | NPC1 (0.50) | HRH3NPC1ALDH1A1KDM4ECYP2D6 | |
| SCHEMBL20128886 | 0.73 | EPHX2 (0.46) | — | |
| SCHEMBL22890944 | 0.71 | NPC1 (0.67) | HRH3NPC1ALDH1A1KCNH2 | |
| SCHEMBL15009138 | 0.71 | NPC1 (0.47) | HRH3NPC1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912699-B2 | Tau-protein targeting compounds and associated | ARVINAS OPERATIONS, INC. (US) | 2024-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11912699-B2 | Tau-protein targeting compounds and associated | MAPT, VHL, CRBN | HRH3 3443/4885NPC1 2550/4885ALDH1A1 3804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.