Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 12/20 | 0.61 |
| ▸ | JAK2 | O60674 | 7/20 | 0.49 |
| ▸ | JAK3 | P52333 | 5/20 | 0.49 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.49 |
| ▸ | BRD2 | P25440 | 2/20 | 0.49 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.49 |
| ▸ | SYK | P43405 | 4/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | BTK | Q06187 | 3/20 | 0.47 |
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | PLK4 | O00444 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | PAK4 | O96013 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | INSR | P06213 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL270076 | 0.91 | BRD4 (0.59) | BRD4JAK2JAK3BRDTBRD2 | |
| Hydrochloric Acid SCHEMBL265273 | 0.90 | BRD4 (0.58) | BRD4JAK2JAK3BRDTBRD2 | |
| SCHEMBL271247 | 0.86 | BRD4 (0.63) | BRD4JAK2JAK3BRDTBRD2 | |
| SCHEMBL271021 | 0.86 | SYK (0.68) | BRD4JAK2JAK3SYKEGFR | |
| SCHEMBL12109589 | 0.86 | BRD4 (0.58) | BRD4JAK2JAK3BRDTBRD2 | |
| SCHEMBL271520 | 0.84 | AURKA (0.51) | BRD4JAK2JAK3SYKEGFR | |
| SCHEMBL13865303 | 0.83 | BRD4 (0.69) | BRD4JAK2JAK3BRDTBRD2 | |
| SCHEMBL271149 | 0.83 | EGFR (0.58) | BRD4JAK2JAK3SYKEGFR | |
| SCHEMBL270949 | 0.82 | BRD4 (0.49) | BRD4SYKAURKAAXLSTK17A | |
| SCHEMBL271050 | 0.81 | AURKA (0.46) | BRD4JAK2JAK3BRDTBRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138199-B2 | Use of bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN, INC. (US) | 2012-03-20 | — | — | US | disclosed |
| US-8133900-B2 | Use of bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN, INC. (US) | 2012-03-13 | — | — | US | disclosed |
| US-20110269721-A1 | METHODS OF TREATING THALASSEMIA | TARGEGEN, INC. (US) | 2011-11-03 | — | — | US | disclosed |
| US-20110212077-A1 | BI-ARYL META-PYRIMIDINE INHIBITORS OF KINASES | TARGEGEN, INC. (US) | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212077-A1 | BI-ARYL META-PYRIMIDINE INHIBITORS OF KINASES | JAK2, TYK2, JAK3 | BRD4 142/4885JAK2 1/4885JAK3 3/4885 |
| US-20110269721-A1 | METHODS OF TREATING THALASSEMIA | JAK2, STAT5A, STAT5B | BRD4 1036/4885JAK2 1/4885JAK3 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.