Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 17/20 | 0.44 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.41 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.39 |
| ▸ | RICTOR | Q6R327 | 4/20 | 0.39 |
| ▸ | MAPKAP1 | Q9BPZ7 | 4/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2710408 | 1.00 | MTOR (0.44) | MTORRPTORMLST8CYP3A4PIK3CA | |
| SCHEMBL10221115 | 0.90 | MTOR (0.49) | MTORRPTORMLST8CYP3A4PIK3CA | |
| SCHEMBL8368149 | 0.88 | MTOR (0.44) | MTORRPTORMLST8CYP3A4PIK3CA | |
| SCHEMBL1833941 | 0.84 | MTOR (0.49) | MTORRPTORMLST8CYP3A4PIK3CA | |
| SCHEMBL1832850 | 0.84 | MTOR (0.49) | MTORRPTORMLST8CYP3A4PIK3CA | |
| Hydrochloric Acid SCHEMBL1834941 | 0.84 | MTOR (0.48) | MTORRPTORMLST8CYP3A4PIK3CA | |
| Hydrochloric Acid SCHEMBL1829119 | 0.84 | MTOR (0.48) | MTORRPTORMLST8CYP3A4PIK3CA | |
| SCHEMBL1830981 | 0.84 | MTOR (0.53) | MTORRPTORMLST8CYP3A4PIK3CA | |
| SCHEMBL1830983 | 0.84 | MTOR (0.53) | MTORRPTORMLST8CYP3A4PIK3CA | |
| SCHEMBL1831622 | 0.83 | MTOR (0.59) | MTORRPTORMLST8CYP3A4PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445346-A1 | OXO-HETEROCYCLE FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Genentech, Inc. (US) | 2012-05-02 | — | — | EP | disclosed |
| US-20100331305-A1 | OXO-HETEROCYCLE FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331305-A1 | OXO-HETEROCYCLE FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| WO-2010151601-A1 | OXO-HETEROCYCLE FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331305-A1 | OXO-HETEROCYCLE FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | MTOR, PIK3CA, RICTOR | MTOR 1/4885RPTOR 15/4885MLST8 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.