Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.51 |
| ▸ | KDR | P35968 | 5/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | MET | P08581 | 2/20 | 0.46 |
| ▸ | TEK | Q02763 | 2/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | FLT1 | P17948 | 2/20 | 0.45 |
| ▸ | FLT4 | P35916 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
| ▸ | STK10 | O94804 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28462680 | 0.88 | JAK2 (0.43) | IRAK4KDRAURKBAURKAMET | |
| SCHEMBL21201011 | 0.87 | KDR (0.44) | IRAK4KDRAURKBAURKAMET | |
| SCHEMBL30616310 | 0.87 | KDR (0.44) | IRAK4KDRAURKBAURKAMET | |
| SCHEMBL31218187 | 0.86 | KDR (0.56) | IRAK4KDRAURKBAURKAMET | |
| SCHEMBL1323767 | 0.86 | KDR (0.56) | IRAK4KDRAURKBAURKAMET | |
| SCHEMBL22505587 | 0.86 | AXL (0.53) | IRAK4KDRAURKBAURKAMET | |
| SCHEMBL25029424 | 0.86 | KDR (0.43) | IRAK4KDRAURKBAURKAMET | |
| SCHEMBL22965528 | 0.86 | TDP1 (0.43) | IRAK4KDRAURKBAURKAMET | |
| SCHEMBL21201270 | 0.85 | IRAK4 (0.43) | IRAK4KDRAURKBAURKAMET | |
| SCHEMBL30616274 | 0.85 | IRAK4 (0.43) | IRAK4KDRAURKBAURKAMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912663-B2 | Multi-targeted tyrosine kinase inhibitors and their pharmaceutical uses | SHANGHAI AB PHARMATECH LTD. (CN) | 2024-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11912663-B2 | Multi-targeted tyrosine kinase inhibitors and their pharmaceutical uses | ABL1, ERBB2, RET | IRAK4 994/4885KDR 429/4885AURKB 278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.