Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 15/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.45 |
| ▸ | KIT | P10721 | 4/20 | 0.45 |
| ▸ | FLT3 | P36888 | 4/20 | 0.45 |
| ▸ | CSF1R | P07333 | 2/20 | 0.45 |
| ▸ | SUV39H1 | O43463 | 1/20 | 0.42 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27110923 | 0.89 | CYP1A2 (0.51) | PDGFRBCYP1A2CYP2D6ENPP1KIT | |
| SCHEMBL22300531 | 0.89 | CYP1A2 (0.55) | PDGFRBCYP1A2CYP2D6ENPP1KIT | |
| SCHEMBL22300529 | 0.88 | CYP1A2 (0.54) | PDGFRBCYP1A2CYP2D6ENPP1KIT | |
| SCHEMBL27111277 | 0.85 | PDGFRB (0.57) | PDGFRBKITFLT3CSF1R | |
| SCHEMBL20813885 | 0.84 | ENPP1 (0.64) | PDGFRBCYP1A2CYP2D6ENPP1KIT | |
| SCHEMBL27111014 | 0.82 | ENPP1 (0.64) | PDGFRBENPP1KITFLT3CSF1R | |
| SCHEMBL22300248 | 0.82 | CYP1A2 (0.59) | CYP1A2CYP2D6ENPP1SUV39H1PRMT1 | |
| SCHEMBL22299724 | 0.82 | CYP1A2 (0.59) | CYP1A2CYP2D6ENPP1SUV39H1PRMT1 | |
| SCHEMBL27111127 | 0.81 | CYP1A2 (0.56) | CYP1A2CYP2D6ENPP1SUV39H1PRMT1 | |
| SCHEMBL27112138 | 0.81 | CYP1A2 (0.80) | PDGFRBCYP1A2CYP2D6ENPP1SUV39H1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4327882-A2 | ENPP1 INHIBITORS AND THEIR USE FOR THE TREATMENT OF CANCER | The Board of Trustees of the Leland Stanford Junior University (US) | 2024-02-28 | — | — | EP | disclosed |