Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 19/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2711020 | 0.89 | PIK3CA (0.49) | KDM4ENPC1PIK3CAPIK3CDPIK3CG | |
| SCHEMBL244071 | 0.81 | KDM4E (0.50) | KDM4ENPC1PIK3CAPIK3CDPIK3CG | |
| SCHEMBL2711981 | 0.81 | KDM4E (0.50) | KDM4ENPC1PIK3CAPIK3CDPIK3CG | |
| SCHEMBL243136 | 0.81 | PIK3CA (0.51) | KDM4ENPC1PIK3CAPIK3CDPIK3CG | |
| SCHEMBL27883188 | 0.79 | DHODH (0.50) | KDM4ENPC1PIK3CAPIK3CDPIK3CG | |
| SCHEMBL27866922 | 0.79 | KDM4E (0.48) | KDM4ENPC1PIK3CAPIK3CDPIK3CG | |
| SCHEMBL13019545 | 0.77 | DHODH (0.50) | KDM4EPIK3CAPIK3CDPIK3CB | |
| SCHEMBL12992702 | 0.74 | PIK3CA (0.46) | KDM4ENPC1PIK3CAPIK3CDPIK3CG | |
| SCHEMBL2711597 | 0.73 | KDM4E (0.50) | KDM4ENPC1PIK3CAPIK3CDPIK3CG | |
| SCHEMBL16597049 | 0.72 | KDM4E (0.59) | KDM4ENPC1PIK3CAPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445886-B1 | 4-AMINOQUINOLINE DERIVATIVES AS PI3K INHIBITORS | AMGEN INC (US) | 2016-03-30 | — | — | EP | disclosed |
| EP-2445886-B1 | 4-AMINOQUINOLINE DERIVATIVES AS PI3K INHIBITORS | AMGEN INC (US) | 2016-03-30 | — | — | EP | disclosed |
| US-8940724-B2 | Quinoline derivitives and their uses | AMGEN INC. (US) | 2015-01-27 | — | — | US | disclosed |
| US-8940724-B2 | Quinoline derivitives and their uses | AMGEN INC. (US) | 2015-01-27 | — | — | US | disclosed |
| US-8940724-B2 | Quinoline derivitives and their uses | AMGEN INC. (US) | 2015-01-27 | — | — | US | disclosed |
| CN-102625799-A | Heterocyclic compounds and their uses | AMGEN INC | 2012-08-01 | — | — | CN | disclosed |
| EP-2445886-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| US-20100331293-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331293-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331293-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-30 | — | — | US | disclosed |
| WO-2010151791-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |
| WO-2010151791-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331293-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, MALT1, BCL9 | KDM4E 2124/4885NPC1 4409/4885PIK3CA 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.